钯催化的N-2,2,2-三氟乙基isatin酮亚胺的不对称（4+3）环加成：获得光学活性螺环吲哚†

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2023-01-01 DOI:10.1039/d3qo00501a

Yinggao Meng , Manman Song , Yue Wang , Yuxin Wang , Er-Qing Li

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引用次数: 0

摘要

报道了钯催化的N-2，2，2-三氟乙基isatin酮亚胺与2-亚甲基三亚甲基碳酸酯的不对称（4+3）环加成反应，以中等产率和良好至优异的ee值对映选择性地得到三氟甲基螺环吲哚。在实验上，反应在没有Brønsted碱的情况下以一锅法顺利进行，这为高效和经济高效地构建光学纯三氟甲基化中型环铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-catalyzed asymmetric (4 + 3) cycloaddition of N-2,2,2-trifluoroethylisatin ketimines: access to optically active spirooxindoles†

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Palladium-catalyzed asymmetric (4 + 3) cycloaddition of N-2,2,2-trifluoroethylisatin ketimines: access to optically active spirooxindoles†

A palladium-catalyzed asymmetric (4 + 3) cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 2-methylidenetrimethylene carbonate was reported to enantioselectively afford trifluoromethylated spirooxindoles in moderate yields and good to excellent ee values. Experimentally, the reaction proceeded smoothly in the absence of a Brønsted base in a one-pot manner, which paved a way for efficient and cost-effective construction of optically pure trifluoromethylated medium-sized rings.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

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0.00%

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