阿米洛利:综述。

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Qianhui Sun, Peter Sever
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引用次数: 26

摘要

阿米洛利是一种保留钾的利尿剂和钠尿剂,其作用是可逆地阻断远端小管晚期和集管的腔上皮钠通道(ENaCs)。阿米洛利适用于水肿状态,作为噻嗪类药物或循环利尿剂的钾保存辅助治疗高血压、充血性心力衰竭和肝硬化伴腹水。其用于高血压的历史研究控制不佳,剂量反应数据不足。在与噻嗪类利尿剂联合使用时,它显然非常有效,可以抵消噻嗪类利尿剂的不良代谢影响,并且在医学研究委员会老年高血压患者试验中,它的使用证明了对中风和冠状动脉事件的令人信服的结果益处。最近,它已被证明在顽固性高血压中与螺内酯一样有效,但确实需要确定它在更大数量的轻度至中度高血压患者中的潜在作用,这些患者缺乏关于阿米洛利的信息,特别是在大剂量范围内。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Amiloride: A review.

Amiloride: A review.

Amiloride: A review.

Amiloride: A review.

Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunctive to thiazide or loop diuretics for hypertension, congestive heart failure and hepatic cirrhosis with ascites. Historical studies on its use in hypertension were poorly controlled and there is insufficient data on dose-response. It is clearly highly effective in combination with thiazide diuretics where it counteracts the adverse metabolic effects of the thiazides and its use in the Medical Research Council Trial of Older Hypertensive Patients, demonstrated convincing outcome benefits on stroke and coronary events. Recently it has been shown to be as effective as spironolactone in resistant hypertension but there is a real need to establish its potential role in the much larger number of patients with mild to moderate hypertension in whom there is a paucity of information with amiloride particularly across an extended dose range.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
16
审稿时长
6-12 weeks
期刊介绍: JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.
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