{"title":"蒙古国乌兰巴托一家三级儿科和妇产医院的革兰氏阴性分离株迅速出现多重耐药性。","authors":"Susanna Felsenstein, Sarantsetseg Bira, Narangerel Altanmircheg, Enkhtur Shonkhuuz, Ariuntuya Ochirpurev, David Warburton","doi":"10.5195/cajgh.2020.371","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Information on microbiological and susceptibility profiles of clinical isolates in Mongolia is scarce, hampering infection control and clinical care.</p><p><strong>Methods: </strong>Species and resistance profiles of 6334 clinical gram negative isolates, collected at Mongolia's National Center for Maternal and Child Health between 2014 and 2017 were analyzed.</p><p><strong>Results: </strong>Annual proportion of multidrug-resistance among <i>E. coli</i> and <i>Enterobacter</i> isolates increased from 2.8% to 16.6% and 3.5% to 22.6% respectively; <i>Klebsiella</i> isolates exhibiting susceptibilities suggestive of extended spectrum beta-lactamase (ESBL) production from 73% to 94%. By 2017, 60.6% of <i>Klebsiella</i> isolates were multidrug-resistant, most originated from intensive care wards. Enterobacteriaceae exhibiting susceptibility patterns suggestive of ESBL production and multidrug-resistant organisms were common and their incidence increased rapidly.</p><p><strong>Conclusion: </strong>These findings will serve to build strategies to strengthen microbiological surveillance, diagnostics and infection control; and to develop empiric therapy and stewardship recommendations for Mongolia's largest Children's and Maternity hospital.</p>","PeriodicalId":42537,"journal":{"name":"Central Asian Journal of Global Health","volume":" ","pages":"e371"},"PeriodicalIF":0.0000,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538878/pdf/","citationCount":"0","resultStr":"{\"title\":\"Rapid Emergence of Multidrug-Resistance among Gram Negative Isolates at a Tertiary Pediatric and Maternity Hospital in Ulaanbaatar, Mongolia.\",\"authors\":\"Susanna Felsenstein, Sarantsetseg Bira, Narangerel Altanmircheg, Enkhtur Shonkhuuz, Ariuntuya Ochirpurev, David Warburton\",\"doi\":\"10.5195/cajgh.2020.371\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Information on microbiological and susceptibility profiles of clinical isolates in Mongolia is scarce, hampering infection control and clinical care.</p><p><strong>Methods: </strong>Species and resistance profiles of 6334 clinical gram negative isolates, collected at Mongolia's National Center for Maternal and Child Health between 2014 and 2017 were analyzed.</p><p><strong>Results: </strong>Annual proportion of multidrug-resistance among <i>E. coli</i> and <i>Enterobacter</i> isolates increased from 2.8% to 16.6% and 3.5% to 22.6% respectively; <i>Klebsiella</i> isolates exhibiting susceptibilities suggestive of extended spectrum beta-lactamase (ESBL) production from 73% to 94%. By 2017, 60.6% of <i>Klebsiella</i> isolates were multidrug-resistant, most originated from intensive care wards. Enterobacteriaceae exhibiting susceptibility patterns suggestive of ESBL production and multidrug-resistant organisms were common and their incidence increased rapidly.</p><p><strong>Conclusion: </strong>These findings will serve to build strategies to strengthen microbiological surveillance, diagnostics and infection control; and to develop empiric therapy and stewardship recommendations for Mongolia's largest Children's and Maternity hospital.</p>\",\"PeriodicalId\":42537,\"journal\":{\"name\":\"Central Asian Journal of Global Health\",\"volume\":\" \",\"pages\":\"e371\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-04-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538878/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Central Asian Journal of Global Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5195/cajgh.2020.371\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central Asian Journal of Global Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5195/cajgh.2020.371","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rapid Emergence of Multidrug-Resistance among Gram Negative Isolates at a Tertiary Pediatric and Maternity Hospital in Ulaanbaatar, Mongolia.
Introduction: Information on microbiological and susceptibility profiles of clinical isolates in Mongolia is scarce, hampering infection control and clinical care.
Methods: Species and resistance profiles of 6334 clinical gram negative isolates, collected at Mongolia's National Center for Maternal and Child Health between 2014 and 2017 were analyzed.
Results: Annual proportion of multidrug-resistance among E. coli and Enterobacter isolates increased from 2.8% to 16.6% and 3.5% to 22.6% respectively; Klebsiella isolates exhibiting susceptibilities suggestive of extended spectrum beta-lactamase (ESBL) production from 73% to 94%. By 2017, 60.6% of Klebsiella isolates were multidrug-resistant, most originated from intensive care wards. Enterobacteriaceae exhibiting susceptibility patterns suggestive of ESBL production and multidrug-resistant organisms were common and their incidence increased rapidly.
Conclusion: These findings will serve to build strategies to strengthen microbiological surveillance, diagnostics and infection control; and to develop empiric therapy and stewardship recommendations for Mongolia's largest Children's and Maternity hospital.
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