血管紧张素转换酶插入/缺失与胶质瘤易感性的遗传多态性:一项荟萃分析。

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-10-01 DOI:10.1177/1470320320963939

Meili Sun, Yuying Fang, Shuzhen Ma, Ximei Gao, Yuping Sun

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引用次数: 2

摘要

目的:血管紧张素转换酶(ACE)插入/缺失(I/D)基因多态性与神经胶质瘤发病风险的研究不一致。因此，我们进行了一项荟萃分析来评估ACE I/D多态性与胶质瘤风险之间的关系。方法与结果:共纳入4个人群(1110例和1335例对照)的ACE I/D多态性。总的来说，荟萃分析显示ACE I/D多态性与胶质瘤风险之间没有显著关联。此外，对ACE I/D多态性与临床分级的相关性分析也显示无显著相关性。结论:我们的荟萃分析没有发现ACE I/D多态性与胶质瘤风险之间的显著关联。然而，需要进一步的更大样本量和更多种族的研究来证实这一结果。

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The genetic polymorphisms of angiotensin converting enzyme insertion/deletion and glioma susceptibility: A meta-analysis.

Objective: The previous studies on angiotensin converting enzyme (ACE) insertion/deletion (I/D) genetic polymorphism and glioma risk were inconsistent. Therefore, we performed a meta-analysis to assess the association between ACE I/D polymorphisms and glioma risk.

Methods and results: In total, four populations (1110 cases and 1335 controls) on ACE I/D polymorphism were included. Overall, the meta-analysis demonstrated no significant association between ACE I/D polymorphism and glioma risk. In addition, the analysis of the association of ACE I/D polymorphism and clinical grade also showed no significant association.

Conclusion: Our meta-analysis didn't find a significant association between ACE I/D polymorphism glioma risk. However, further studies with larger sample size and more ethnic groups are required to confirm the results.

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.