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引用次数: 13
摘要
ELOVL2 (Very Long Chain Fatty Acids-Like 2的延伸)启动子的DNA甲基化是实足年龄最强大的分子生物标志物之一，但ELOVL2是否在衰老中发挥功能作用尚未被探索。ELOVL2编码一种跨膜蛋白，参与超长多不饱和脂肪酸(VLC-PUFAs)的合成。这些脂肪酸在视网膜生物学和光感受器更新中发挥重要作用，这是与年龄相关的眼病(如年龄相关性黄斑变性(AMD))有关的关键过程。在这里，我们总结了我们破译ELOVL2在眼睛中的作用的工作，强调了与年龄相关的DNA甲基化在AMD病理生理中的潜在功能作用。
DNA methylation of the ELOVL2 (Elongation Of Very Long Chain Fatty Acids-Like 2) promoter is one of the most robust molecular biomarkers for chronological age, but whether ELOVL2 plays a functional role in aging has not been explored. ELOVL2 encodes a transmembrane protein involved in the synthesis of very long polyunsaturated fatty acids (VLC-PUFAs). These fatty acids play important roles in retinal biology and photoreceptor renewal, key processes implicated in age-related eye diseases such as age-related macular degeneration (AMD). Here, we summarize our work deciphering the role of ELOVL2 in the eye emphasizing the potential functional role of age-related DNA methylation in the pathophysiology of AMD.
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