Jesse Lopes da Silva, Bruno Henrique Rala de Paula, Isabele Avila Small, Luiz Claudio Santos Thuler, Andréia Cristina de Melo
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Most patients had advanced clinical stage (III: 85.1%; cT3/T4: 86.4%; cN1-3: 74.4%) and high-grade tumors (72.1%). Clinical staging (III vs II, adjusted hazard ratio [HR] = 2.95, <i>P</i> = .012) significantly influenced the pCR rate. Alcohol intake negatively influenced EFS (adjusted HR = 1.67, <i>P</i> = .006) and OS (adjusted HR = 1.89, <i>P</i> = .005). Women with pCR showed better EFS (crude HR = 0.15, <i>P</i> < .001) and OS (crude HR = 0.12, <i>P</i> < .001) compared with non-pCR. The ypT (<0.001) and ypN (<0.001) gradually influenced survival outcomes.</p><p><strong>Conclusion: </strong>Clinical stage III were associated with lower response rate and worse survival. 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They have been assessed for pathological complete response (pCR), event-free survival (EFS), and overall survival (OS). Both univariate and multivariate Cox regression analyses were performed.</p><p><strong>Results: </strong>The median follow-up was 64.3 months. Most patients had advanced clinical stage (III: 85.1%; cT3/T4: 86.4%; cN1-3: 74.4%) and high-grade tumors (72.1%). Clinical staging (III vs II, adjusted hazard ratio [HR] = 2.95, <i>P</i> = .012) significantly influenced the pCR rate. Alcohol intake negatively influenced EFS (adjusted HR = 1.67, <i>P</i> = .006) and OS (adjusted HR = 1.89, <i>P</i> = .005). Women with pCR showed better EFS (crude HR = 0.15, <i>P</i> < .001) and OS (crude HR = 0.12, <i>P</i> < .001) compared with non-pCR. The ypT (<0.001) and ypN (<0.001) gradually influenced survival outcomes.</p><p><strong>Conclusion: </strong>Clinical stage III were associated with lower response rate and worse survival. 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引用次数: 5
摘要
目的:评价社会人口学、临床和病理因素与三阴性乳腺癌(TNBC)接受新辅助化疗(NACT)的疗效和生存率的关系。方法:从2010年至2014年期间在巴西国家癌症研究所接受NACT和手术诊断的235名符合条件的三阴癌妇女的医疗记录中获得临床病理和社会人口学数据。对患者进行病理完全缓解(pCR)、无事件生存期(EFS)和总生存期(OS)的评估。进行单因素和多因素Cox回归分析。结果:中位随访时间为64.3个月。多数患者临床分期为晚期(III期:85.1%;cT3 / T4: 86.4%;cN1-3: 74.4%)和高级别肿瘤(72.1%)。临床分期(III vs II，校正风险比[HR] = 2.95, P = 0.012)显著影响pCR率。酒精摄入对EFS(校正HR = 1.67, P = 0.006)和OS(校正HR = 1.89, P = 0.005)有负面影响。经pCR治疗的患者EFS较好(粗HR = 0.15, P P)。结论:临床ⅲ期患者有效率较低，生存率较差。酒精摄入、pCR和nact后残留疾病负担对生存结果有相当大的影响。
Sociodemographic, Clinical, and Pathological Factors Influencing Outcomes in Locally Advanced Triple Negative Breast Cancer: A Brazilian Cohort.
Objective: To evaluate the association of sociodemographic, clinical, and pathological factors with response and survival in triple negative breast cancer (TNBC) undergoing neoadjuvant chemotherapy (NACT).
Methods: Clinical-pathological and sociodemographic data were obtained from medical records of 235 eligible women with TNBC diagnosed between 2010 and 2014 undergoing NACT and surgery at the Brazilian National Cancer Institute. They have been assessed for pathological complete response (pCR), event-free survival (EFS), and overall survival (OS). Both univariate and multivariate Cox regression analyses were performed.
Results: The median follow-up was 64.3 months. Most patients had advanced clinical stage (III: 85.1%; cT3/T4: 86.4%; cN1-3: 74.4%) and high-grade tumors (72.1%). Clinical staging (III vs II, adjusted hazard ratio [HR] = 2.95, P = .012) significantly influenced the pCR rate. Alcohol intake negatively influenced EFS (adjusted HR = 1.67, P = .006) and OS (adjusted HR = 1.89, P = .005). Women with pCR showed better EFS (crude HR = 0.15, P < .001) and OS (crude HR = 0.12, P < .001) compared with non-pCR. The ypT (<0.001) and ypN (<0.001) gradually influenced survival outcomes.
Conclusion: Clinical stage III were associated with lower response rate and worse survival. Alcohol intake, pCR, and burden of post-NACT residual disease have shown considerable influence on survival outcomes.
期刊介绍：
Breast Cancer: Basic and Clinical Research is an international, open access, peer-reviewed, journal which considers manuscripts on all areas of breast cancer research and treatment. We welcome original research, short notes, case studies and review articles related to breast cancer-related research. Specific areas of interest include, but are not limited to, breast cancer sub types, pathobiology, metastasis, genetics and epigenetics, mammary gland biology, breast cancer models, prevention, detection, therapy and clinical interventions, and epidemiology and population genetics.
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