Raymond Pranata, Rudi Supriyadi, Ian Huang, Hikmat Permana, Michael Anthonius Lim, Emir Yonas, Nanny Natalia M Soetedjo, Antonia Anna Lukito
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CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], <i>P</i> = .03; <i>I</i> <sup>2</sup> = 51%, <i>P</i> = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], <i>P</i> = .009; <i>I</i> <sup>2</sup> = 14%, <i>P</i> = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], <i>P</i> = .05; <i>I</i> <sup>2</sup> = 57%, <i>P</i> = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 87%, <i>P</i> < .001), including mortality (RR 26.02 [5.01, 135.13], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 60%, <i>P</i> = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], <i>P</i> = .008; <i>I</i> <sup>2</sup> = 81%, <i>P</i> < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], <i>P</i> < .01; <i>I</i> <sup>2</sup> = 0%, <i>P</i> < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], <i>P</i> < .0005).</p><p><strong>Conclusion: </strong>CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.</p>","PeriodicalId":44269,"journal":{"name":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","volume":"14 ","pages":"1179548420959165"},"PeriodicalIF":1.0000,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179548420959165","citationCount":"43","resultStr":"{\"title\":\"The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.\",\"authors\":\"Raymond Pranata, Rudi Supriyadi, Ian Huang, Hikmat Permana, Michael Anthonius Lim, Emir Yonas, Nanny Natalia M Soetedjo, Antonia Anna Lukito\",\"doi\":\"10.1177/1179548420959165\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients.</p><p><strong>Methodology: </strong>A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator.</p><p><strong>Results: </strong>Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], <i>P</i> = .03; <i>I</i> <sup>2</sup> = 51%, <i>P</i> = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], <i>P</i> = .009; <i>I</i> <sup>2</sup> = 14%, <i>P</i> = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], <i>P</i> = .05; <i>I</i> <sup>2</sup> = 57%, <i>P</i> = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 87%, <i>P</i> < .001), including mortality (RR 26.02 [5.01, 135.13], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 60%, <i>P</i> = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], <i>P</i> = .008; <i>I</i> <sup>2</sup> = 81%, <i>P</i> < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], <i>P</i> < .01; <i>I</i> <sup>2</sup> = 0%, <i>P</i> < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], <i>P</i> < .0005).</p><p><strong>Conclusion: </strong>CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.</p>\",\"PeriodicalId\":44269,\"journal\":{\"name\":\"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine\",\"volume\":\"14 \",\"pages\":\"1179548420959165\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2020-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/1179548420959165\",\"citationCount\":\"43\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/1179548420959165\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine Insights-Circulatory Respiratory and Pulmonary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1179548420959165","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 43
摘要
目的:本研究旨在评估慢性肾脏疾病(CKD)和新发肾脏替代治疗(RRT)与2019冠状病毒病(COVID-19)患者预后的关系。方法:从多个数据库中对评估CKD、RRT使用和COVID-19结局的研究进行了系统的文献检索。不良预后的组合包括死亡率、严重COVID-19、急性呼吸窘迫综合征(ARDS)、需要重症监护和使用机械呼吸机。结果:19项研究共纳入7216例患者。CKD与综合不良预后增加相关(RR 2.63 [1.33, 5.17]， P = .03;I 2 = 51%， P = 0.01)及其亚组，包括死亡率(RR 3.47 [1.36, 8.86]， P = 0.009;我2 = 14%,P = 32)严重COVID-19 (RR 2.89 [0.98, 8.46], P = . 05;I 2 = 57%， p = .04)。RRT与综合不良预后增加(RR 18.04 [4.44, 73.25]， p2 = 87%， p2 = 60%， P = 0.06)、重症COVID-19 (RR 12.95 [1.93, 86.82]， P = 0.008;结论:CKD和新发RRT与COVID-19患者预后不良相关。
The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.
Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients.
Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator.
Results: Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], P = .03; I2 = 51%, P = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], P = .009; I2 = 14%, P = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], P = .05; I2 = 57%, P = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], P < .001; I2 = 87%, P < .001), including mortality (RR 26.02 [5.01, 135.13], P < .001; I2 = 60%, P = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], P = .008; I2 = 81%, P < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], P < .01; I2 = 0%, P < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], P < .0005).
Conclusion: CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.
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