Raymond Pranata, Rudi Supriyadi, Ian Huang, Hikmat Permana, Michael Anthonius Lim, Emir Yonas, Nanny Natalia M Soetedjo, Antonia Anna Lukito
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CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], <i>P</i> = .03; <i>I</i> <sup>2</sup> = 51%, <i>P</i> = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], <i>P</i> = .009; <i>I</i> <sup>2</sup> = 14%, <i>P</i> = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], <i>P</i> = .05; <i>I</i> <sup>2</sup> = 57%, <i>P</i> = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 87%, <i>P</i> < .001), including mortality (RR 26.02 [5.01, 135.13], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 60%, <i>P</i> = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], <i>P</i> = .008; <i>I</i> <sup>2</sup> = 81%, <i>P</i> < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], <i>P</i> < .01; <i>I</i> <sup>2</sup> = 0%, <i>P</i> < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], <i>P</i> < .0005).</p><p><strong>Conclusion: </strong>CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179548420959165","citationCount":"43","resultStr":"{\"title\":\"The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.\",\"authors\":\"Raymond Pranata, Rudi Supriyadi, Ian Huang, Hikmat Permana, Michael Anthonius Lim, Emir Yonas, Nanny Natalia M Soetedjo, Antonia Anna Lukito\",\"doi\":\"10.1177/1179548420959165\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients.</p><p><strong>Methodology: </strong>A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. 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RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 87%, <i>P</i> < .001), including mortality (RR 26.02 [5.01, 135.13], <i>P</i> < .001; <i>I</i> <sup>2</sup> = 60%, <i>P</i> = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], <i>P</i> = .008; <i>I</i> <sup>2</sup> = 81%, <i>P</i> < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], <i>P</i> < .01; <i>I</i> <sup>2</sup> = 0%, <i>P</i> < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], <i>P</i> < .0005).</p><p><strong>Conclusion: </strong>CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2020-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/1179548420959165\",\"citationCount\":\"43\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/1179548420959165\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1179548420959165","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 43
摘要
目的:本研究旨在评估慢性肾脏疾病(CKD)和新发肾脏替代治疗(RRT)与2019冠状病毒病(COVID-19)患者预后的关系。方法:从多个数据库中对评估CKD、RRT使用和COVID-19结局的研究进行了系统的文献检索。不良预后的组合包括死亡率、严重COVID-19、急性呼吸窘迫综合征(ARDS)、需要重症监护和使用机械呼吸机。结果:19项研究共纳入7216例患者。CKD与综合不良预后增加相关(RR 2.63 [1.33, 5.17]， P = .03;I 2 = 51%， P = 0.01)及其亚组，包括死亡率(RR 3.47 [1.36, 8.86]， P = 0.009;我2 = 14%,P = 32)严重COVID-19 (RR 2.89 [0.98, 8.46], P = . 05;I 2 = 57%， p = .04)。RRT与综合不良预后增加(RR 18.04 [4.44, 73.25]， p2 = 87%， p2 = 60%， P = 0.06)、重症COVID-19 (RR 12.95 [1.93, 86.82]， P = 0.008;结论:CKD和新发RRT与COVID-19患者预后不良相关。
The Association Between Chronic Kidney Disease and New Onset Renal Replacement Therapy on the Outcome of COVID-19 Patients: A Meta-analysis.
Objective: The aim of the study was to evaluate the association between chronic kidney disease (CKD) and new onset renal replacement therapy (RRT) with the outcome of Coronavirus Disease 2019 (COVID-19) in patients.
Methodology: A systematic literature search from several databases was performed on studies that assessed CKD, use of RRT, and the outcome of COVID-19. The composite of poor outcome consisted of mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), need for intensive care, and use of mechanical ventilator.
Results: Nineteen studies with a total of 7216 patients were included. CKD was associated with increased composite poor outcome (RR 2.63 [1.33, 5.17], P = .03; I2 = 51%, P = .01) and its subgroup, consisting of mortality (RR 3.47 [1.36, 8.86], P = .009; I2 = 14%, P = .32) and severe COVID-19 (RR 2.89 [0.98, 8.46], P = .05; I2 = 57%, P = .04). RRT was associated with increased composite poor outcome (RR 18.04 [4.44, 73.25], P < .001; I2 = 87%, P < .001), including mortality (RR 26.02 [5.01, 135.13], P < .001; I2 = 60%, P = .06), severe COVID-19 (RR 12.95 [1.93, 86.82], P = .008; I2 = 81%, P < .001), intensive care (IC) (RR 14.22 [1.76, 114.62], P < .01; I2 = 0%, P < .98), and use of mechanical ventilator (RR 34.39 [4.63, 255.51], P < .0005).
Conclusion: CKD and new-onset RRT were associated with poor outcome in patients with COVID-19.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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