钯催化的烯醇的级联环化/分子内氧化还原中继Heck芳基化：从2-（羟基烯基）磺酰苯胺获得四氢-β-卡宾†

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2023-01-01 DOI:10.1039/d3qo00620d

Tao Liu , Tuanli Yao , Ruihua Guo , Xiangyang Qin

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引用次数: 0

摘要

提出了一种钯催化的级联反应，将钯催化的炔烃环化和烯醇的分子内氧化还原中继Heck芳基化相结合，由2-（羟基烯基）磺酰胺合成四氢-β-碳啉和其他多环吲哚。这种方法能够在一次操作中构建两个环并安装一个远程羰基，为进一步的精细化提供了广泛的合成用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-catalyzed cascade cyclization/intramolecular redox-relay Heck arylation of alkenols: access to tetrahydro-β-carbolines from 2-(hydroxyalkenynyl)sulfonanilides†

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Palladium-catalyzed cascade cyclization/intramolecular redox-relay Heck arylation of alkenols: access to tetrahydro-β-carbolines from 2-(hydroxyalkenynyl)sulfonanilides†

A palladium-catalyzed cascade reaction for the synthesis of tetrahydro-β-carbolines and other polycyclic indoles from 2-(hydroxyenyl)sulfonanilides by combining the Pd(ii)-catalyzed cyclization of alkynes and intramolecular redox-relay Heck arylation of alkenols is presented. This method enables the construction of two rings and installs a remote carbonyl group in a single operation, offering broad synthetic utility for further elaborations.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量