皮肤血管炎和肉芽肿性肝炎是英夫利昔单抗的矛盾不良事件。

IF 1 4区医学 Q4 RHEUMATOLOGY

Acta reumatologica portuguesa Pub Date : 2020-04-01

DIogo Esperança Almeida, Emanuel Costa, Joana Sousa Neves, Marcos Cerqueira, Ana Roxo Ribeiro

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引用次数: 0

摘要

生物制剂彻底改变了炎性关节病的治疗。反常不良反应(PAEs)是此类药物引起的罕见免疫副作用。作者报告了一名银屑病关节炎患者同时出现两种罕见的肿瘤坏死因子α抑制剂(iTNFa) -皮肤血管炎和肉芽肿性肝炎-的PAEs，并根据现有证据简要讨论了这些事件的诊断、病理生理学和处理方面。

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Cutaneous vasculitis and granulomatous hepatitis as paradoxical adverse events of Infliximab.

Biological agents revolutionised the treatment of inflammatory arthropathies. Paradoxical adverse events (PAEs) are rare immunological side effects caused by such agents. The authors report concurrent presentation of two rare PAEs of tumor-necrosis-factor alpha inhibitors (iTNFa) - cutaneous vasculitis and granulomatous hepatitis - in a patient with psoriatic arthritis treated with infliximab and briefly discuss aspects of diagnosis, pathophysiology and management of such events in light of the available evidence.

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来源期刊

Acta reumatologica portuguesa 医学-风湿病学

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Reumatólogica Portuguesa is a scientific peer reviewed journal covering all aspects of rheumatic diseases and related to Rheumatology. The journal publishes original articles, reviews, clinical cases, images in rheumatology, letters to the editor and clinical teaching (e.g. guidelines and clinical protocols). Published since 1973, Acta Reumatológica Portuguesa is the official scientific publication of the Portuguese Society of Rheumatology, a non-profit organization that promotes the knowledge and investigation of rheumatic diseases and the development of Rheumatology.