左非诺普利与雷米普利在急性心肌梗死合并收缩功能障碍早期的对比:一项回顾性研究。

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-07-01 DOI:10.1177/1470320320946530

Xiaoyang Liu, Xiaoling Xu, Yi Chu, Yingang Ren, Liping Wang

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引用次数: 2

摘要

SMILE研究报告了急性心肌梗死早期佐非诺普利优于雷米普利的预后益处，但这些益处尚未在中国人群的临床实践中进行测试。本研究的目的是比较急性心肌梗死患者佐非诺普利加阿司匹林与雷米普利加阿司匹林的有效性和安全性。方法:急性心肌梗死早期患者每日服用唑非诺普利30 mg (ZF组，N=191)或雷米普利5 mg (RP组，N=256)，外加阿司匹林100 mg /d。收集和分析了有关心血管疾病住院、非心血管事件和死亡率的数据。结果:1年治疗期间，ZF组47例(25%)和RP组97例(40%)患者因心血管疾病住院(p=0.002)， ZF组3例(2%)和RP组14例(6%)患者死亡(p=0.043)。在ZF队列中，干咳(p=0.001)和贫血(p=0.049)的发生率较低。结论:该研究建议急性心肌梗死合并收缩功能障碍患者长期服用唑非普利与100mg阿司匹林。

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Zofenopril versus ramipril in the early phase of acute myocardial infarction with systolic dysfunction: A retrospective study.

Introduction: Prognostic benefits of zofenopril over ramipril in the early phase of acute myocardial infarction have been reported by the SMILE study, but these benefits have not been tested in clinical practice in the Chinese population. The objective of this study was to compare the effectiveness and safety of zofenopril plus aspirin against ramipril plus aspirin in patients with acute myocardial infarction.

Methods: Patients in the early phase of acute myocardial infarction received 30 mg zofenopril (ZF cohort, N=191) or 5 mg ramipril (RP cohort, N=256) b.i.d. plus 100 mg aspirin/day. Data regarding hospitalisation for cardiovascular disease, non-cardiovascular events and mortality were collected and analysed.

Results: During 1 year of treatment, 47 (25%) patients in the ZF cohort and 97 (40%) patients in the RP cohort were hospitalised due to cardiovascular disease (p=0.002), and three (2%) patients in the ZF cohort and 14 (6%) patients in the RP cohort died (p=0.043). Lower incidences of dry cough (p=0.001) and anaemia (p=0.049) were reported in the ZF cohort.

Conclusions: The study recommends zofenopril with 100 mg aspirin for a longer period in patients with acute myocardial infarction with systolic dysfunction.

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.