通过DNA折纸揭示抗体-抗原相互作用的动力学。

IF 3.1 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Research in Chinese Universities Pub Date : 2020-01-01 Epub Date: 2020-08-18 DOI:10.1007/s40242-020-0252-6

Zhou Nie

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引用次数: 0

摘要

为了研究抗体与抗原之间的动态相互作用，Fan等人合理设计了一个三角形DNA折纸框架，在纳米尺度上对抗原表位进行空间组织，从而监测室温下动态抗原-抗体复合物的瞬时结合动力学。本研究提供了一种简单、可设计和可编程的策略来研究单分子水平上抗体-抗原相互作用的转移动力学，并提高对设计用于各种生物医学应用的下一代抗体和疫苗的理解。这项工作已于2020年6月19日在线发表在《自然通讯》上。

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Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami.

To investigate the dynamic interaction between antibody and antigen, Fan et al. rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room temperature. This study provides a straightforward, designable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve the understanding toward the design of the next-generation antibodies and vaccines for various biomedical applications. This work has been published online in Nature Communications on June 19, 2020.

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来源期刊

Chemical Research in Chinese Universities 化学-化学综合

CiteScore

5.30

自引率

6.50%

发文量

152

审稿时长

3.0 months

期刊介绍： The journal publishes research articles, letters/communications and reviews written by faculty members, researchers and postgraduates in universities, colleges and research institutes all over China and overseas. It reports the latest and most creative results of important fundamental research in all aspects of chemistry and of developments with significant consequences across subdisciplines. Main research areas include (but are not limited to): Organic chemistry (synthesis, characterization, and application); Inorganic chemistry (bio-inorganic chemistry, inorganic material chemistry); Analytical chemistry (especially chemometrics and the application of instrumental analysis and spectroscopy); Physical chemistry (mechanisms, catalysis, thermodynamics and dynamics); Polymer chemistry and polymer physics (mechanisms, material, catalysis, thermodynamics and dynamics); Quantum chemistry (quantum mechanical theory, quantum partition function, quantum statistical mechanics); Biochemistry; Biochemical engineering; Medicinal chemistry; Nanoscience (nanochemistry, nanomaterials).