numular湿疹:最新综述。

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
Alexander K C Leung, Joseph M Lam, Kin Fon Leong, Amy A M Leung, Alex H C Wong, Kam L Hon
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引用次数: 13

摘要

背景:钱币状湿疹可能与环状结构的疾病相似,鉴别诊断广泛。目的:本文旨在提供最新的评估,诊断和治疗钱币湿疹。方法:以“钱币状湿疹”、“盘状湿疹”或“钱币状皮炎”为关键词进行PubMed检索。检索策略包括荟萃分析、随机对照试验、临床试验、观察性研究和综述。搜索仅限于英国文学。从上述搜索中检索到的信息用于编写本文。在www.google.com/patents和www.freepatentsonline.com.Results中使用关键词“钱币状湿疹”、“盘状湿疹”或“钱币状皮炎”进行专利检索:钱币状湿疹的特征是轮廓分明、椭圆形或硬币形、红斑、湿疹斑块。通常,病变的大小在直径1到10cm之间。病变通常为多发且对称分布。偏爱的部位包括下肢,其次是上肢。病变通常有强烈的瘙痒感。临床诊断主要基于弥漫性皮肤干燥患者的圆形至椭圆形红斑斑块的特征。钱币状湿疹应与其他环状病变区分开来。皮肤镜检查可以显示对正确诊断有价值的其他特征。通常不需要活检或实验室检查。然而,如果怀疑有体癣,则应对皮肤刮痕进行氢氧化钾湿法检查。因为接触性过敏在钱币性湿疹中很常见,对于慢性顽固性钱币性湿疹患者应考虑进行斑贴试验。避免沉淀因素,最佳的皮肤护理和高或超高效能的局部皮质类固醇是主要的治疗方法。最近的专利有关管理钱币湿疹也进行了讨论。结论:通过适当的治疗,钱币湿疹可以在几周内清除,尽管过程可能是慢性的,并以复发和缓解为特征。皮肤保湿和避免可识别的加重因素,如热水浴和刺激性肥皂可以减少复发的频率。出现环状病变的疾病可能类似于钱币性湿疹,鉴别诊断很广泛。因此,医生必须熟悉这种情况,以便做出准确的诊断,并开始适当的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nummular Eczema: An Updated Review.

Background: Nummular eczema may mimic diseases that present with annular configuration and the differential diagnosis is broad.

Objective: This article aimed to provide an update on the evaluation, diagnosis, and treatment of nummular eczema.

Methods: A PubMed search was performed in using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to English literature. The information retrieved from the above search was used in the compilation of the present article. Patents were searched using the key terms "nummular eczema", "discoid eczema", OR "nummular dermatitis" in www.google.com/patents and www.freepatentsonline.com.

Results: Nummular eczema is characterized by sharply defined, oval or coin-shaped, erythematous, eczematous plaques. Typically, the size of the lesion varies from 1 to 10cm in diameter. The lesions are usually multiple and symmetrically distributed. Sites of predilection include the lower limbs followed by the upper limbs. The lesions are usually intensely pruritic. The diagnosis is mainly clinical based on the characteristic round to oval erythematous plaques in a patient with diffusely dry skin. Nummular eczema should be distinguished from other annular lesions. Dermoscopy can reveal additional features that can be valuable for correct diagnosis. Biopsy or laboratory tests are generally not necessary. However, a potassium hydroxide wet-mount examination of skin scrapings should be performed if tinea corporis is suspected. Because contact allergy is common with nummular eczema, patch testing should be considered in patients with chronic, recalcitrant nummular eczema. Avoidance of precipitating factors, optimal skin care, and high or ultra-high potency topical corticosteroids are the mainstay of therapy. Recent patents related to the management of nummular eczema are also discussed.

Conclusion: With proper treatment, nummular eczema can be cleared over a few weeks, although the course can be chronic and characterized by relapses and remissions. Moisturizing of the skin and avoidance of identifiable exacerbating factors, such as hot water baths and harsh soaps may reduce the frequency of recurrence. Diseases that present with annular lesions may mimic nummular eczema and the differential diagnosis is broad. As such, physicians must be familiar with this condition so that an accurate diagnosis can be made, and appropriate treatment initiated.

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来源期刊
CiteScore
3.90
自引率
0.00%
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期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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