阿根廷电化学发光法测定新生儿和婴儿FSH、LH、睾酮、雌二醇、皮质醇和DHEA-S的参考区间。

4区医学 Q2 Medicine

Pediatric endocrinology reviews : PER Pub Date : 2020-06-01 DOI:10.17458/per.vol17.2020.tsm.Neonatalinfantintervalsargentina

Cintia Soledad Tarifa, Liliana Karina Silvano, Silvia Edith Martin, Veronica Campi, Maria Cecilia Aguirre, Gabriela Maria Sobrero, Mariana Ochetti, Mirta Beatriz Miras, Noemi Liliana Muñoz

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引用次数: 1

摘要

背景:由于方法上的差异，不同实验室获得的促性腺激素和类固醇浓度通常不能进行比较。目的:根据年龄和性别确定新生儿第一年FSH、LH、T、E2、F和DHEA-S的参考区间。方法:在阿根廷Córdoba的Niños医院招募1236名健康婴儿(1-365天)。采用电化学发光Cobas e601分析仪对血清样品进行分析。估计参考区间及其置信限。结果:女性FSH水平高于男性。男性的LH和T水平较高。60天后，E2水平在两性之间存在差异。F水平表现出很大的差异，没有性别差异。DHEA-S水平在出生时较高，在第一年下降。结论:这些参考区间有助于提高1岁新生儿内分泌失调的诊断能力。

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Neonatal and Infant Reference Intervals for FSH, LH, Testosterone, Estradiol, Cortisol and DHEA-S by Electrochemiluminescence in Argentina.

Background: Gonadotropin and steroid concentrations obtained in various laboratories cannot often be compared because of methodological differences.

Aims: to determine reference intervals for FSH, LH, T, E2, F and DHEA-S according to age and sex during the first year of life.

Methods: 1236 healthy infants (1-365 days of age) were recruited at Hospital de Niños in Córdoba, Argentina. Serum samples were analyzed using electrochemiluminescence, Cobas e601 analyzer. Reference Intervals and their confidence limits were estimated.

Results: Female FSH levels were higher than in males. LH and T levels were higher in males. E2 levels showed a difference between sexes after 60 days of age. F levels showed a wide variation, without differences between sexes. DHEA-S levels were higher at birth and decreased during the first year.

Conclusion: These reference intervals may help to increase the diagnostic power for the assessment of endocrine disorders during the first year of life.

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Pediatric endocrinology reviews : PER Medicine-Endocrinology, Diabetes and Metabolism

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期刊介绍： PEDIATRIC ENDOCRINOLOGY REVIEWS (PER) publishes scholarly review articles in all areas of clinical and experimental Endocrinology, Diabetes, Nutrition and Metabolism. PER is intended for practicing pediatricians, pediatric endocrinologists, pediatric diabetologists, pediatric gastroenterologists, neonatologists, pediatric gynecologists, nutritionists, sport physicians and pediatricians-in-training. PER will also publish topics on specific subjects or as proceedings of scientific meetings in the above fields of interest. All articles, whether invited or direct contributions, are peer-reviewed. PER publishes correspondence, book reviews, a meeting calendar and meeting reports.