女性的内分泌系统与饮酒。

IF 9 1区 医学 Q1 SUBSTANCE ABUSE
Alcohol Research : Current Reviews Pub Date : 2020-07-23 eCollection Date: 2020-01-01 DOI:10.35946/arcr.v40.2.02
Deborah A Finn
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引用次数: 29

摘要

在临床和临床前研究中已经证实了终生酒精暴露对两性二态的影响。过去,男性的酒精使用障碍(AUD)率高于女性,但在过去10年里,酒精使用障碍和酗酒患病率的性别差异已经缩小。最近的证据增加了关于性类固醇对饮酒的影响以及与压力相关类固醇的相互作用的历史数据。本文综述了内分泌系统对女性饮酒的影响,重点讨论了下丘脑垂体-性腺轴和下丘脑垂体-肾上腺轴及其相互作用。重点是临床前研究,这些研究检查了雌激素、孕激素、糖皮质激素和gaba能神经类固醇对饮酒和复发模型的基因组和快速膜效应。与男性数据的相关比较强调了性类固醇和应激类固醇对饮酒的不同影响,并强调了在开发治疗AUD的新型药物治疗靶点时考虑性别的重要性。例如,针对促肾上腺皮质激素释放因子和糖皮质激素受体系统的药理学策略在男性和女性中可能效果不同,而增强gaba能神经类固醇的策略可能是两性治疗效果的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Endocrine System and Alcohol Drinking in Females.

The Endocrine System and Alcohol Drinking in Females.

The Endocrine System and Alcohol Drinking in Females.

The Endocrine System and Alcohol Drinking in Females.

Sexually dimorphic effects of alcohol exposure throughout life have been documented in clinical and preclinical studies. In the past, rates of alcohol use disorder (AUD) were higher in men than in women, but over the past 10 years, the difference between sexes in prevalence of AUD and binge drinking has narrowed. Recent evidence adds to historical data regarding the influence of sex steroids on alcohol drinking and the interaction with stress-related steroids. This review considers the contribution of the endocrine system to alcohol drinking in females, with a focus on the hypothalamic pituitary gonadal axis and the hypothalamic pituitary adrenal axis and their reciprocal interactions. Emphasis is given to preclinical studies that examined genomic and rapid membrane effects of estrogen, progesterone, glucocorticoids, and GABAergic neurosteroids for their effects on alcohol drinking and models of relapse. Pertinent comparisons to data in males highlight divergent effects of sex and stress steroids on alcohol drinking and emphasize the importance of considering sex in the development of novel pharmacotherapeutic targets for the treatment of AUD. For instance, pharmacological strategies targeting the corticotropin releasing factor and glucocorticoid receptor systems may be differentially effective in males and females, whereas strategies to enhance GABAergic neurosteroids may represent a biomarker of treatment efficacy in both sexes.

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来源期刊
自引率
1.10%
发文量
0
期刊介绍: Alcohol Research: Current Reviews (ARCR) is an open-access, peer-reviewed journal published by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) at the National Institutes of Health. Starting from 2020, ARCR follows a continuous, rolling publication model, releasing one virtual issue per yearly volume. The journal offers free online access to its articles without subscription or pay-per-view fees. Readers can explore the content of the current volume, and past volumes are accessible in the journal's archive. ARCR's content, including previous titles, is indexed in PubMed, PsycINFO, Scopus, and Web of Science.
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