临床试验中的无创血红蛋白监测:系统综述和荟萃分析

IF 1 Q3 Medicine

Revista brasileira de anestesiologia Pub Date : 2020-07-01 DOI:10.1016/j.bjan.2019.05.006

Tailyne Zortéa , Daniele Paola da Silva Wizbicki , Kristian Madeira , Pedro Gabriel Ambrosio , Rafaela Okchstein Borges de Souza , Edson Souza Machado Durães

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引用次数: 1

摘要

背景和目的通过共氧法测量血红蛋白是一项创新技术，通过连续、无创和快速监测获得的血红蛋白浓度(Hb)测量信息的处理提供了效率和敏捷性。由于这一特性，它可以减少用于评估和其他不必要治疗的血液样本数量，从而避免患者不必要地暴露于侵入性手术。它还有助于决定是否需要输血以及如何处理输血。本研究的目的是比较Masimo Corporation (Irvine, CA, USA)仪器和标准金工具(实验室检查)在获得Hb值时提供的性能。该研究对应于系统评价，随后进行meta分析，其中包括1990年至2018年发表的完全注册的全文临床试验。调查了PubMed、Cochrane、Medline、Embase和Web of Science数据库。无创和有创血红蛋白监测方法的平均总差异为0.23 (95% CI‐0.16,0.62)，即无统计学意义(p = 0.250)。研究内部和研究之间的异质性分析结果表明高度不一致(Q = 461.63, p <0.0001, I2 = 98%)， Hb值的方法。结论:虽然无创Hb测量与金标准法之间的平均差异很小，但co -血氧计可以作为一种无创“趋势”监测，用于检测Hb水平的意外反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Monitorização não invasiva da hemoglobina em ensaios clínicos: uma revisão sistemática e metanálise

查看原文本刊更多论文

Monitorização não invasiva da hemoglobina em ensaios clínicos: uma revisão sistemática e metanálise

Background and objectives

The measurement of Hb by co‐oximetry is an innovative technique that offers efficiency and agility in the processing of information regarding the measurement of Hemoglobin concentration (Hb) obtained through continuous, non‐invasive and rapid monitoring. Because of this attribute, it avoids unnecessary exposures of the patient to invasive procedures by allowing a reduction in the number of blood samples for evaluation and other unnecessary therapies. It also helps to make decisions about the need for transfusion and how to handle it. The objective of this study is to compare the performance offered to obtain Hb values between the Masimo Corporation (Irvine, CA, USA) instrument and the standard gold tool (laboratory examination).

The study corresponds to a systematic review followed by meta‐analysis, which included fully registered full‐text clinical trials published from 1990 to 2018. PubMed, Cochrane, Medline, Embase and Web of Science databases were investigated. The mean overall difference found between the non‐invasive and invasive methods of hemoglobin monitoring was 0.23 (95% CI ‐0.16, 0.62), that is, it did not present statistical significance (p = 0.250). The results of the analysis of heterogeneity within and between the studies indicated high levels of inconsistency (Q = 461.63, p < 0.0001, I² = 98%), method for Hb values.

Conclusions

Although the mean difference between noninvasive measurements of Hb and the gold standard method is small, the co‐oximeter can be used as a non‐invasive “trend” monitor in detecting unexpected responses at Hb levels.

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来源期刊

Revista brasileira de anestesiologia ANESTHESIOLOGY-

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： The Brazilian Journal of Anesthesiology is the official journal of the Brazilian Anesthesiology Society. It publishes articles classified into the following categories: -Scientific articles (clinical or experimental trials)- Clinical information (case reports)- Reviews- Letters to the Editor- Editorials. The journal focuses primarily on clinical trials, with scope on clinical practice, aiming at providing applied tools to the anesthesiologist and critical care physician. The Brazilian Journal of Anesthesiology accepts articles exclusively forwarded to it. Articles already published in other journals are not accepted. All articles proposed for publication are previously submitted to the analysis of two or more members of the Editorial Board or other specialized consultants.