啮齿动物基于奖惩的决策。

Q2 Neuroscience
Caitlin A Orsini, Nicholas W Simon
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引用次数: 6

摘要

决策缺陷是许多精神疾病的核心,如药物滥用障碍和注意缺陷多动障碍。因此,啮齿动物的决策模型与理解适应性选择行为背后的神经机制以及这些机制如何在病理条件下受到损害是密切相关的。为了确保做出最佳决策,必须将奖励价值与结果的发生结合起来,这是一个关键因素,它可以根据概率(惩罚风险)和时间连续性(延迟惩罚)而有所不同。本文将重点讨论涉及明确惩罚的两种决策模型,这两种模型都概括了人类决策过程中后果的不同方面。我们将讨论每种行为方案,设计实验时要考虑的参数,以及最后如何将这些动物模型用于精神疾病的研究。©2020 Wiley期刊有限责任公司基本协议1:行为训练支持协议:设备测试备用协议:奖励歧视基本协议2:风险决策任务(RDT)基本协议3:延迟惩罚决策任务(DPDT)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reward/Punishment-Based Decision Making in Rodents.

Deficits in decision making are at the heart of many psychiatric diseases, such as substance abuse disorders and attention deficit hyperactivity disorder. Consequently, rodent models of decision making are germane to understanding the neural mechanisms underlying adaptive choice behavior and how such mechanisms can become compromised in pathological conditions. A critical factor that must be integrated with reward value to ensure optimal decision making is the occurrence of consequences, which can differ based on probability (risk of punishment) and temporal contiguity (delayed punishment). This article will focus on two models of decision making that involve explicit punishment, both of which recapitulate different aspects of consequences during human decision making. We will discuss each behavioral protocol, the parameters to consider when designing an experiment, and finally how such animal models can be utilized in studies of psychiatric disease. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Behavioral training Support Protocol: Equipment testing Alternate Protocol: Reward discrimination Basic Protocol 2: Risky decision-making task (RDT) Basic Protocol 3: Delayed punishment decision-making task (DPDT).

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来源期刊
Current Protocols in Neuroscience
Current Protocols in Neuroscience Neuroscience-Neuroscience (all)
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期刊介绍: Current Protocols in Neuroscience is a one-stop resource for finding and adapting the best models and methods for all types of neuroscience experiments. Updated every three months in all formats, CPNS is constantly evolving to keep pace with the very latest discoveries and developments. A year of these quarterly updates is included in the initial CPNS purchase price.
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