鸟类atp结合盒亚家族G成员2基因亚家族及其类似物的分子进化。

IF 3.4 Q1 Agricultural and Biological Sciences
Shengchao Ma, Hehe Liu, Wenqiang Sun, Ahsan Mustafa, Yang Xi, Fajun Pu, Yanying Li, Chunchun Han, Lili Bai, He Hua
{"title":"鸟类atp结合盒亚家族G成员2基因亚家族及其类似物的分子进化。","authors":"Shengchao Ma,&nbsp;Hehe Liu,&nbsp;Wenqiang Sun,&nbsp;Ahsan Mustafa,&nbsp;Yang Xi,&nbsp;Fajun Pu,&nbsp;Yanying Li,&nbsp;Chunchun Han,&nbsp;Lili Bai,&nbsp;He Hua","doi":"10.1186/s12862-020-01654-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.</p><p><strong>Results: </strong>We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.</p><p><strong>Conclusions: </strong>We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.</p>","PeriodicalId":9111,"journal":{"name":"BMC Evolutionary Biology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12862-020-01654-z","citationCount":"2","resultStr":"{\"title\":\"Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.\",\"authors\":\"Shengchao Ma,&nbsp;Hehe Liu,&nbsp;Wenqiang Sun,&nbsp;Ahsan Mustafa,&nbsp;Yang Xi,&nbsp;Fajun Pu,&nbsp;Yanying Li,&nbsp;Chunchun Han,&nbsp;Lili Bai,&nbsp;He Hua\",\"doi\":\"10.1186/s12862-020-01654-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.</p><p><strong>Results: </strong>We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.</p><p><strong>Conclusions: </strong>We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.</p>\",\"PeriodicalId\":9111,\"journal\":{\"name\":\"BMC Evolutionary Biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2020-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s12862-020-01654-z\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Evolutionary Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s12862-020-01654-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Evolutionary Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s12862-020-01654-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 2

摘要

背景:atp结合盒(ABC)转运体参与多种内源性或外源性物质的主动运输。在鸟类中已鉴定出两个ABCG2基因亚家族成员。对ABCG2和ABCG2样基因进行详细的比较研究,有助于我们在分子水平上了解它们的进化史,并为研究ABCG2和ABCG2样基因在鸟类中的具体功能提供理论参考。结果:首次在41只鸟类基因组中鉴定出77个ABCG2/ABCG2样基因序列。进一步分析表明,ABCG2和ABCG2样基因的核酸和氨基酸序列在鸟类中高度保守,具有高度同源性。然而,ABCG2和ABCG2样氨基酸序列的n端结构存在显著差异。选择压力分析表明,ABCG2和ABCG2样基因在鸟类进化过程中受到纯化选择的影响。结论:我们认为鸟类祖先的4号染色体上存在多个ABCG2基因亚家族成员。在漫长的进化过程中,鸟类的4号染色体上只保留了ABCG2基因。6号染色体上的abcg2样基因可能起源于染色体复制或融合。ABCG2蛋白N端与ABCG2样蛋白N端结构上的差异可能导致相应基因功能上的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.

Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds.

Background: ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds.

Results: We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution.

Conclusions: We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
BMC Evolutionary Biology
BMC Evolutionary Biology 生物-进化生物学
CiteScore
5.80
自引率
0.00%
发文量
0
审稿时长
6 months
期刊介绍: BMC Evolutionary Biology is an open access, peer-reviewed journal that considers articles on all aspects of molecular and non-molecular evolution of all organisms, as well as phylogenetics and palaeontology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信