儿童未来健康结局的DNA甲基化生物标志物

IF 2.4 Q1 PEDIATRICS
Shivanthan Shanthikumar, Melanie R Neeland, Jovana Maksimovic, Sarath C Ranganathan, Richard Saffery
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引用次数: 6

摘要

预测未来健康结果的生物标志物是实现精准健康目标的关键。这些生物标志物不必参与疾病的因果途径,它们的性能最好通过临床性能的统计测试和净健康影响评估来评估。DNA甲基化是最常研究的表观遗传过程,代表了未来健康结果的潜在生物标志物。我们回顾了25项非肿瘤性儿科疾病的研究,其中评估了DNA甲基化生物标志物对未来健康结果的影响。虽然已经描述了一些积极的发现,但由于结果测量、组织特异性样本、考虑样本细胞类型异质性、缺乏适当的统计测试、效应量小、验证有限以及未评估净健康影响等问题,证据体受到严重限制。未来的研究应该集中在仔细的研究设计上,以克服这些问题,并将DNA甲基化数据与其他“组学”、临床和环境数据相结合,以产生临床上最有用的儿科疾病生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

DNA methylation biomarkers of future health outcomes in children.

DNA methylation biomarkers of future health outcomes in children.

Biomarkers which predict future health outcomes are key to the goals of precision health. Such biomarkers do not have to be involved in the causal pathway of a disease, and their performance is best assessed using statistical tests of clinical performance and evaluation of net health impact. DNA methylation is the most commonly studied epigenetic process and represents a potential biomarker of future health outcomes. We review 25 studies in non-oncological paediatric conditions where DNA methylation biomarkers of future health outcomes are assessed. Whilst a number of positive findings have been described, the body of evidence is severely limited by issues with outcome measures, tissue-specific samples, accounting for sample cell type heterogeneity, lack of appropriate statistical testing, small effect sizes, limited validation, and no assessment of net health impact. Future studies should concentrate on careful study design to overcome these issues, and integration of DNA methylation data with other 'omic', clinical, and environmental data to generate the most clinically useful biomarkers of paediatric disease.

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