婴儿出生体重的跨代倾向反映了恒河猴母亲的胎儿生长历史。

Trends in developmental biology Pub Date : 2019-12-01
Elizabeth A Shirtcliff, Gabriele R Lubach, Reilly Mooney, Robert T Beck, Laurel K Fanning, Christopher L Coe
{"title":"婴儿出生体重的跨代倾向反映了恒河猴母亲的胎儿生长历史。","authors":"Elizabeth A Shirtcliff,&nbsp;Gabriele R Lubach,&nbsp;Reilly Mooney,&nbsp;Robert T Beck,&nbsp;Laurel K Fanning,&nbsp;Christopher L Coe","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Birth weight (BW) at delivery is an important developmental milestone indicative of prenatal conditions and portends of the postnatal growth trajectory that will occur during infancy and childhood. Previous research has documented that there are also many physiological and health consequences of being born either small-for-gestational age (SGA) or large-for-gestational age (LGA). Analyses of breeding animals have demonstrated further that a gravid female exerts a strong influence on the size of her infant by term, and this permissiveness or constraint over fetal growth can be transmitted from mothers to their daughters. The following research tested additional hypotheses about matrilineal effects on BW by examining records from a large breeding colony of rhesus monkeys across multiple generations. The analyses utilized BW of 1710 infant monkeys obtained over 4 decades. In addition to determining the association between the birth weight (BW) of a female and her own infants birthed later as a mother, the multi-generational transmission of birth size from a grandmother through her daughters to the next generation was examined. Other maternal influences were evident, including a progressive increase in infant BW with parity, which synergized with matrilineal effects across a female's reproductive life. In addition, our modeling indicated that if an infant's BW was discordant-a SGA female birthing a larger daughter-the discrepant fetal growth pattern could be accentuated in the next generation. Overall, the findings confirm that the size of an infant at term is significantly influenced by a type of gestational imprinting on daughters during the prenatal period, which then continues to shape birth outcomes in subsequent generations.</p>","PeriodicalId":75257,"journal":{"name":"Trends in developmental biology","volume":"12 ","pages":"55-65"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331457/pdf/nihms-1600388.pdf","citationCount":"0","resultStr":"{\"title\":\"Transgenerational propensities for infant birth weight reflect fetal growth history of the mother in rhesus monkeys.\",\"authors\":\"Elizabeth A Shirtcliff,&nbsp;Gabriele R Lubach,&nbsp;Reilly Mooney,&nbsp;Robert T Beck,&nbsp;Laurel K Fanning,&nbsp;Christopher L Coe\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Birth weight (BW) at delivery is an important developmental milestone indicative of prenatal conditions and portends of the postnatal growth trajectory that will occur during infancy and childhood. Previous research has documented that there are also many physiological and health consequences of being born either small-for-gestational age (SGA) or large-for-gestational age (LGA). Analyses of breeding animals have demonstrated further that a gravid female exerts a strong influence on the size of her infant by term, and this permissiveness or constraint over fetal growth can be transmitted from mothers to their daughters. The following research tested additional hypotheses about matrilineal effects on BW by examining records from a large breeding colony of rhesus monkeys across multiple generations. The analyses utilized BW of 1710 infant monkeys obtained over 4 decades. In addition to determining the association between the birth weight (BW) of a female and her own infants birthed later as a mother, the multi-generational transmission of birth size from a grandmother through her daughters to the next generation was examined. Other maternal influences were evident, including a progressive increase in infant BW with parity, which synergized with matrilineal effects across a female's reproductive life. In addition, our modeling indicated that if an infant's BW was discordant-a SGA female birthing a larger daughter-the discrepant fetal growth pattern could be accentuated in the next generation. Overall, the findings confirm that the size of an infant at term is significantly influenced by a type of gestational imprinting on daughters during the prenatal period, which then continues to shape birth outcomes in subsequent generations.</p>\",\"PeriodicalId\":75257,\"journal\":{\"name\":\"Trends in developmental biology\",\"volume\":\"12 \",\"pages\":\"55-65\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331457/pdf/nihms-1600388.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in developmental biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in developmental biology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

出生体重(BW)在分娩时是一个重要的发育里程碑,表明产前条件和预示出生后的生长轨迹,将发生在婴儿期和儿童期。先前的研究已经证明,小胎龄(SGA)或大胎龄(LGA)出生也有许多生理和健康后果。对繁殖动物的分析进一步表明,怀孕的雌性对其婴儿的大小有很强的影响,这种对胎儿生长的纵容或限制可以从母亲传递给女儿。接下来的研究通过检查一个大型恒河猴繁殖群体的多代记录,测试了关于母系对体重影响的其他假设。分析利用了40多年来获得的1710只幼猴的体重。除了确定女性的出生体重(BW)与其后来作为母亲出生的婴儿之间的关系外,还研究了出生体重从祖母通过她的女儿到下一代的多代传递。母系的其他影响也很明显,包括胎次后婴儿体重的逐渐增加,这与母系效应在雌性生殖寿命中的协同作用。此外,我们的模型表明,如果一个婴儿的体重不一致——SGA雌性生出一个更大的女儿——胎儿生长模式的差异可能会在下一代中加剧。总的来说,研究结果证实,足月婴儿的大小受到产前对女儿的一种妊娠印记的显著影响,这种印记随后继续影响后代的出生结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Transgenerational propensities for infant birth weight reflect fetal growth history of the mother in rhesus monkeys.

Birth weight (BW) at delivery is an important developmental milestone indicative of prenatal conditions and portends of the postnatal growth trajectory that will occur during infancy and childhood. Previous research has documented that there are also many physiological and health consequences of being born either small-for-gestational age (SGA) or large-for-gestational age (LGA). Analyses of breeding animals have demonstrated further that a gravid female exerts a strong influence on the size of her infant by term, and this permissiveness or constraint over fetal growth can be transmitted from mothers to their daughters. The following research tested additional hypotheses about matrilineal effects on BW by examining records from a large breeding colony of rhesus monkeys across multiple generations. The analyses utilized BW of 1710 infant monkeys obtained over 4 decades. In addition to determining the association between the birth weight (BW) of a female and her own infants birthed later as a mother, the multi-generational transmission of birth size from a grandmother through her daughters to the next generation was examined. Other maternal influences were evident, including a progressive increase in infant BW with parity, which synergized with matrilineal effects across a female's reproductive life. In addition, our modeling indicated that if an infant's BW was discordant-a SGA female birthing a larger daughter-the discrepant fetal growth pattern could be accentuated in the next generation. Overall, the findings confirm that the size of an infant at term is significantly influenced by a type of gestational imprinting on daughters during the prenatal period, which then continues to shape birth outcomes in subsequent generations.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信