应用一氧化二氮测定脑血流量

Q3 Arts and Humanities

Journal of Anesthesia History Pub Date : 2020-06-01 DOI:10.1016/j.janh.2020.02.004

Linda Y. Tang , Jingping Wang , Theodore A. Alston

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引用次数: 0

摘要

在20世纪40年代，Seymour S. Kety和Carl F. Schmidt通过吸入亚麻醉剂量的氧化亚氮来测量清醒人类的脑血流量。吸入途径不需要动脉注射指示剂，氧化亚氮具有代谢惰性，通过血脑屏障快速扩散，血液和脑溶解度相当，易于分析检测的优点。这项技术也被应用于心脏。Kety的后续工作促进了脑部扫描方法的发展。

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Kety-Schmidt Application of Nitrous Oxide to Determine Cerebral Blood Flow

In the 1940s, Seymour S. Kety and Carl F. Schmidt measured cerebral blood flow in awake humans by means of subanesthetic doses of inhaled nitrous oxide. The inhalation route obviated the need for an arterial injection of the indicator, and nitrous oxide had virtues of metabolic inertness, rapid diffusion through the blood-brain barrier, comparable blood and brain solubility, and ease of analytical detection. The technique was also applied to the heart. Follow-up work by Kety contributed to the development of brain scanning methods.

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来源期刊

Journal of Anesthesia History Arts and Humanities-History and Philosophy of Science

自引率

0.00%

发文量

期刊介绍： The Journal of Anesthesia History (ISSN 2352-4529) is an international peer-reviewed journal dedicated to advancing the study of anesthesia history and related disciplines. The Journal addresses anesthesia history from antiquity to the present. Its wide scope includes the history of perioperative care, pain medicine, critical care medicine, physician and nurse practices of anesthesia, equipment, drugs, and prominent individuals. The Journal serves a diverse audience of physicians, nurses, dentists, clinicians, historians, educators, researchers and academicians.