站在病毒的肩膀上

IF 12.1 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ari Helenius
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引用次数: 2

摘要

我和我的同事利用动物病毒及其与宿主细胞的相互作用来研究其他方法难以研究的细胞过程。这种方法使我们能够在许多方向上进行分支,包括膜蛋白表征,内吞作用,分泌,蛋白质折叠,质量控制和糖生物学。与此同时,我们的目标是利用细胞生物学方法扩大对动物病毒及其致病方式的基本了解。我们研究了宿主细胞的进入和进入的病毒的脱衣机制,以及病毒蛋白和分子组装的合成、折叠、成熟和细胞内运动。我有幸在四个不同国家的机构工作过。早年在芬兰(赫尔辛基大学),随后在德国(欧洲分子生物学实验室)度过了6年,在美国(耶鲁医学院)度过了16年,在瑞士(苏黎世联邦理工学院)度过了16年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Standing on the Shoulders of Viruses.

My coworkers and I have used animal viruses and their interaction with host cells to investigate cellular processes difficult to study by other means. This approach has allowed us to branch out in many directions, including membrane protein characterization, endocytosis, secretion, protein folding, quality control, and glycobiology. At the same time, our aim has been to employ cell biological approaches to expand the fundamental understanding of animal viruses and their pathogenic lifestyles. We have studied mechanisms of host cell entry and the uncoating of incoming viruses as well as the synthesis, folding, maturation, and intracellular movement of viral proteins and molecular assemblies. I have had the privilege to work in institutions in four different countries. The early years in Finland (the University of Helsinki) were followed by 6 years in Germany (European Molecular Biology Laboratory), 16 years in the United States (Yale School of Medicine), and 16 years in Switzerland (ETH Zurich).

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来源期刊
Annual review of biochemistry
Annual review of biochemistry 生物-生化与分子生物学
CiteScore
33.90
自引率
0.00%
发文量
31
期刊介绍: The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.
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