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引用次数: 11
摘要
神经突生长抑制剂- b (Neurite outgrowth inhibitor-B, Nogo-B)是一种广泛表达于多器官,尤其是血管内皮细胞和血管平滑肌细胞的膜蛋白,属于网状蛋白家族。值得注意的是,NUS1编码的特异性受体Nogo-B受体(NgBR)参与了许多关键的细胞过程,如胆固醇转运、脂质代谢、醇合成、蛋白质n -糖基化、血管重构、血管生成、肿瘤发生和神经发育。近年来,越来越多的研究表明,NgBR表达水平在人类疾病中的变化具有统计学意义,包括Niemann-Pick C型病、脂肪肝、先天性糖基化障碍、新生儿持续性肺动脉高压、浸润性导管性乳腺癌、恶性黑色素瘤、非小细胞肺癌、小儿癫痫、帕金森病等。此外,体外和体内研究均表明,NgBR过表达或敲低可导致多种病理生理过程的改变。因此,通过调节NgBR的表达水平,在治疗策略上具有广阔的发展潜力。
Research advances on neurite outgrowth inhibitor B receptor.
Neurite outgrowth inhibitor‐B (Nogo‐B) is a membrane protein which is extensively expressed in multiple organs, especially in endothelial cells and vascular smooth muscle cells of blood vessels and belongs to the reticulon protein family. Notably, its specific receptor, Nogo‐B receptor (NgBR), encoded by NUS1, has been implicated in many crucial cellular processes, such as cholesterol trafficking, lipid metabolism, dolichol synthesis, protein N‐glycosylation, vascular remodelling, angiogenesis, tumorigenesis and neurodevelopment. In recent years, accumulating studies have demonstrated the statistically significant changes of NgBR expression levels in human diseases, including Niemann‐Pick type C disease, fatty liver, congenital disorders of glycosylation, persistent pulmonary hypertension of the newborn, invasive ductal breast carcinoma, malignant melanoma, non‐small cell lung carcinoma, paediatric epilepsy and Parkinson's disease. Besides, both the in vitro and in vivo studies have shown that NgBR overexpression or knockdown contribute to the alteration of various pathophysiological processes. Thus, there is a broad development potential in therapeutic strategies by modifying the expression levels of NgBR.
期刊介绍:
Bridging physiology and cellular medicine, and molecular biology and molecular therapeutics, Journal of Cellular and Molecular Medicine publishes basic research that furthers our understanding of the cellular and molecular mechanisms of disease and translational studies that convert this knowledge into therapeutic approaches.