短毛母草抗血脂异常及抗氧化活性研究舒尔茨。链脲佐菌素诱导的糖尿病大鼠。

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871525718666200506100139

Ayoub Amssayef, Bouchra El Azzaoui, Mohammed Ajebli, Mohamed Eddouks

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引用次数: 1

摘要

目的:研究毛蕊草的降血脂和抗氧化活性。背景:母羊属植物(Desf.)Shultz是一种菊科植物，传统上常用于治疗糖尿病。目的:研究毛蕊草(Matricaria pubescens)的抗氧化活性。舒尔兹及其对正常及链脲佐菌素诱导的糖尿病大鼠血脂和脂蛋白谱的影响。方法:以40 mg/kg剂量反复口服短毛茛(MPAE)水提物(MPAE)，观察其对正常及链脲佐菌素诱导的糖尿病大鼠血脂及脂蛋白谱的影响。此外，采用FRAP和ABTS两种方法对其酚类、类黄酮和单宁含量及抗氧化活性进行了初步筛选和定量。结果:MPAE通过降低血清甘油三酯、总胆固醇和低密度脂蛋白(LDL)水平，在糖尿病大鼠中显示出有效的抗血脂异常作用。此外，结果表明，提取物富含多种植物化学物质，并显示出重要的抗氧化活性。结论:综上所述，本研究证明了母刺草(Matricaria pubescens, Desf.)舒尔茨。对糖尿病性血脂异常有良好作用。

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Antidyslipidemic and Antioxidant Activities of Matricaria pubescens (Desf.) Shultz. in Streptozotocin-Induced Diabetic Rats.

Aims: The study aimed to evaluate the antihyperlipidemic and antioxidant activities of Matricaria pubescens.

Background: Matricaria pubescens (Desf.) Shultz belongs to Asteraceae family and it is commonly used traditionally for handling diabetes mellitus.

Objective: The objective of this study was to assess the antioxidant activity of Matricaria pubescens (Desf.) Shultz and its effect on lipid and lipoprotein profile in normal and streptozotocin-induced diabetic rats.

Methods: The effect of repeated (7 days of treatment) oral administration of the aqueous extracts of aerial part of Matricaria pubescens (MPAE) at a dose of 40 mg/kg on lipid and lipoprotein profile was examined in normal and streptozotocin-induced diabetic rats. Furthermore, a preliminary phytochemical screening and the quantification of phenolic, flavonoid and tannin contents as well as the antioxidant activity using two methods (FRAP and ABTS) were carried out.

Results: MPAE demonstrated a potent antidyslipidemic effect in diabetic rats by reducing serum levels of triglycerides, total cholesterol and Low-Density Lipoprotein (LDL). In addition, the results showed that the extract is rich in several phytochemical compounds and revealed an important antioxidant activity.

Conclusion: In summary, this study proved that Matricaria pubescens (Desf.) Shultz. has a favorable effect on diabetic dyslipidemia.

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.