自发性颅内出血患者QT间期与院内死亡率的关系

Advanced Journal of Emergency Medicine Pub Date : 2019-08-29 eCollection Date: 2020-01-01 DOI:10.22114/ajem.v0i0.190
Seyyed Mahdi Zia Ziabari, Neda Akhundzadeh, Maryam Shakiba, Pedram Keshavarz
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引用次数: 3

摘要

复极异常如QT间期延长、ST段和T波改变是颅内出血(ICH)患者最常见的心电图改变。最近有研究建议,延长QTc间隔会增加因恶性室性心律失常或心源性猝死而死亡的风险。目的:本研究的目的是评价脑出血患者QT间期与死亡的关系。方法:对2015-2017年在伊朗拉什特Poursina医院转诊的脑出血患者进行横断面研究。QT间期根据BAZETT公式人工测定。最大QT、最大QTc和QT离散度是患者心电图评价的变量。研究的结果是住院期间患者的死亡或生存。结果:共纳入病例466例,平均年龄69±12岁,其中男性68.7%。平均QTc-Max间隔为350.4±56.5毫秒,平均QTc-Max间隔为583.6±57.6毫秒。总死亡率为22.7%。QTc-MAX与死亡之间存在显著的统计学关系(p=0.001)。但QT-MAX与预后无统计学意义(p=0.593)。结论:QT间期延长可能与脑出血患者住院死亡率相关。因此,评估心电图异常,特别是延长的QTc对这些患者可能是有价值的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Relationship Between QT Interval and Intra-Hospital Mortality in patients with Spontaneous Intracranial Hemorrhage.

Introduction: Repolarization abnormalities such as prolongation of QT interval and changes in ST segment and T wave are the most usual electrocardiogram (ECG) changes in patients with intracranial hemorrhage (ICH). It has recently been recommended that prolonged QTc interval raises the risk of death due to malignant ventricular arrhythmias or sudden cardiac death.

Objective: The goal of this study was to evaluate the relationship between QT interval and death in patients with ICH.

Method: This cross-sectional study was performed on patients with ICH who referred during 2015-2017 to Poursina Hospital, Rasht, Iran. The QT interval was manually measured based on the BAZETT formula. Max QT and Max QTc and QT dispersion were the variables evaluated by the ECG of the patients. The outcome under the study was the death or survival of patients during hospitalization.

Results: Finally, 466 cases with the mean age of 69±12 years were studied of whom 68.7% were male. The average QT-Max interval was 350.4±56.5 milliseconds, and the average QTc-Max was 583.6±57.6 msec. Totally, 22.7% of the patients died. There was a significant statistical relationship between QTc-MAX and death (p=0.001). However, there was no statistically significant relationship between QT-MAX and the outcome (p=0.593).

Conclusion: It is likely that, prolonged QT interval is correlated with in-hospital mortality of patients with ICH. Therefore, it can be expected that assessing ECG abnormalities, especially prolonged QTc could be valuable in these patients.

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