Mohamed A Rowisha, Mohamed R El-Shanshory, Eslam E El-Hawary, Amira Youssef Ahmed, Shafeq Ryad Mustafa Altoraky
{"title":"母婴因素对脐带CD34+细胞的影响。","authors":"Mohamed A Rowisha, Mohamed R El-Shanshory, Eslam E El-Hawary, Amira Youssef Ahmed, Shafeq Ryad Mustafa Altoraky","doi":"10.21037/sci.2020.03.01","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The achievement of optimal number of CD34<sup>+</sup> umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34<sup>+</sup> cell count.</p><p><strong>Methods: </strong>The study was done on umbilical cord blood samples obtained from 20 mothers during labor. Their ages ranged from 22 to 34 years and were subjected to history taking, physical examination of the baby and assessment of the CD34<sup>+</sup> cells count in umbilical cord blood.</p><p><strong>Results: </strong>Number of previous live births and weight of the baby had a significant effect on CD34<sup>+</sup> cells count while the sex of the baby, delivery route, maternal age and gestation period had no significant effect on CD34<sup>+</sup> cells count.</p><p><strong>Conclusions: </strong>Umbilical cord blood-derived CD34<sup>+</sup> cell count is better with good weight and first babies and decreased with subsequent babies.</p>","PeriodicalId":21938,"journal":{"name":"Stem cell investigation","volume":"7 ","pages":"5"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/sci.2020.03.01","citationCount":"3","resultStr":"{\"title\":\"Impact of maternal and neonatal factors on umbilical cord CD34<sup>+</sup> cells.\",\"authors\":\"Mohamed A Rowisha, Mohamed R El-Shanshory, Eslam E El-Hawary, Amira Youssef Ahmed, Shafeq Ryad Mustafa Altoraky\",\"doi\":\"10.21037/sci.2020.03.01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The achievement of optimal number of CD34<sup>+</sup> umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34<sup>+</sup> cell count.</p><p><strong>Methods: </strong>The study was done on umbilical cord blood samples obtained from 20 mothers during labor. Their ages ranged from 22 to 34 years and were subjected to history taking, physical examination of the baby and assessment of the CD34<sup>+</sup> cells count in umbilical cord blood.</p><p><strong>Results: </strong>Number of previous live births and weight of the baby had a significant effect on CD34<sup>+</sup> cells count while the sex of the baby, delivery route, maternal age and gestation period had no significant effect on CD34<sup>+</sup> cells count.</p><p><strong>Conclusions: </strong>Umbilical cord blood-derived CD34<sup>+</sup> cell count is better with good weight and first babies and decreased with subsequent babies.</p>\",\"PeriodicalId\":21938,\"journal\":{\"name\":\"Stem cell investigation\",\"volume\":\"7 \",\"pages\":\"5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.21037/sci.2020.03.01\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stem cell investigation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21037/sci.2020.03.01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stem cell investigation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/sci.2020.03.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Impact of maternal and neonatal factors on umbilical cord CD34+ cells.
Background: The achievement of optimal number of CD34+ umbilical cord stem cells is essential for successful umbilical cord stem cell transplantation. So the aim of this study was to assess the potential effect of both maternal and neonatal factors on the umbilical cord blood CD34+ cell count.
Methods: The study was done on umbilical cord blood samples obtained from 20 mothers during labor. Their ages ranged from 22 to 34 years and were subjected to history taking, physical examination of the baby and assessment of the CD34+ cells count in umbilical cord blood.
Results: Number of previous live births and weight of the baby had a significant effect on CD34+ cells count while the sex of the baby, delivery route, maternal age and gestation period had no significant effect on CD34+ cells count.
Conclusions: Umbilical cord blood-derived CD34+ cell count is better with good weight and first babies and decreased with subsequent babies.
期刊介绍：
The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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