改良根治性前列腺切除术治疗高级别前列腺癌尿失禁的疗效观察。

Q1 Medicine

Minerva Urologica E Nefrologica Pub Date : 2020-10-01 Epub Date: 2020-04-16 DOI:10.23736/S0393-2249.20.03633-4

Jae W Chung, Sang W Kim, Ho W Kang, Yun S Ha, Seock H Choi, Jun N Lee, Bum S Kim, Hyun T Kim, Tae H Kim, Ghil S Yoon, Tae G Kwon, Sung K Chung, Eun S Yoo

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引用次数: 6

摘要

背景:本研究旨在评估高度前列腺癌(PCa)根治性前列腺切除术(RP)后尿失禁恢复的预测因素。方法:回顾性分析2011年1月至2018年5月在韩国一个中心接受RP治疗的241例高级别(Gleason评分为8或9)PCa患者。尿失禁定义为不使用尿垫。在RP后1、3、6和12个月评估尿失禁。单因素和多因素分析确定RP术后尿失禁恢复的预测因素。结果:患者平均年龄67.6±6.4岁，PSA平均值18.7±21.1 ng/dL。共有197例(81.7%)患者接受了保留神经的RP, 198例(82.2%)患者在RP后1年未行手术。多因素分析显示，年龄(比值比[OR]=1.091 [1.015-1.172]， P=0.018)、体重指数(BMI) (OR=1.227 [1.057-1.424]， P=0.007)和改良手术技术(OR=0.109 [0.044-0.267]， P)是高级别PCa患者RP术后尿失禁恢复的独立预测因素。这些发现可能有助于外科医生对RP后尿失禁恢复的高级别PCa患者提供术前和术后建议。

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Efficacy of modified radical prostatectomy technique for recovery of urinary incontinence in high-grade prostate cancer.

Background: This study was conducted to evaluate predictive factors of urinary continence recovery after radical prostatectomy (RP) for high-grade prostate cancer (PCa).

Methods: A total of 241 patients with high-grade (Gleason Score 8 or 9) PCa who underwent RP in a single Korean center between January 2011 and May 2018 were retrospectively reviewed. Urinary continence was defined as no pads use. Urinary continence was evaluated at 1, 3, 6, and 12 months after RP. Univariate and multivariate analyses were performed to determine the predictive factors of urinary continence recovery after RP.

Results: The mean age was 67.6±6.4 years, and the mean PSA was 18.7±21.1 ng/dL. A total of 197 (81.7%) patients underwent nerve-sparing RP, and 198 patients (82.2%) were continent 1 year after RP. Multivariate analysis showed that the age (odds ratio [OR]=1.091 [1.015-1.172], P=0.018), Body Mass Index (BMI) (OR=1.227 [1.057-1.424], P=0.007), and modified surgical technique (OR=0.109 [0.044-0.267], P<0.001) were independent factors for predicting urinary continence recovery after RP.

Conclusions: Younger age, low BMI, and modified surgery were independent predictors of urinary continence recovery after RP in patients with high-grade PCa. These findings may help surgeons to give pre- and postoperative advice to patients with high-grade PCa about urinary continence recovery after RP.

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来源期刊

Minerva Urologica E Nefrologica UROLOGY & NEPHROLOGY-

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Minerva Urologica e Nefrologica publishes scientific papers on nephrology and urology. Manuscripts may be submitted in the form of Minerva opinion editorials, editorial comments, original articles, video illustrated articles, review articles and letters to the Editor.