Ding-Hua Shi, Hui-Jie Zhou, Bin-Bin Wang, Yan-Hong Gu, Yi-Fei Wang
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Multiple sequence alignment of the M protein in SARS-associated and other known coronaviruses.
In this paper, we report a multiple sequence alignment result on the basis of 10 amino acid sequences of the M protein, which come from different coronaviruses (4 SARS-associated and 6 others known). The alignment model was based on the profile HMM (Hidden Markov Model), and the model training was implemented through the SAHMM (Self-Adapting Hidden Markov Model) software developed by the authors.
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