Kawa Amin, Sulaf Mosa Issa, Kosar Mohammad Ali, Muaid Ismiel Aziz, Huner Mohamed Hama Amieen, Jonas Bystrom, Christer Janson
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Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient.</p><p><strong>Conclusions: </strong>Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. 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引用次数: 16
摘要
背景:目的是测定变应性鼻炎(AR)患者炎症因子、嗜酸性阳离子蛋白和IgE水平。研究对象和方法:采集88例AR患者和88例健康对照者的血液样本。流式细胞术检测各样品嗜酸性粒细胞计数，ECLIA检测IgE, ECP检测IL-17, ELISA检测IL-33。结果:AR患者与对照组在年龄、性别上无显著差异。AR患者的嗜酸性粒细胞、IgE、ECP、IL-17、IL-33水平及总症状评分均显著高于HC (P = 0.0001)。r组患者血清ECP与IL-17 (P = 0.041, r = 0.42)、IL-33 (P = 0.0001, r = 080)、IgE水平(P = 0.017, r = 0.45)相关。IL-17与IL-33之间无相关性。患者的症状评分与嗜酸性粒细胞(P = 0.026, r = 0.52)、IgE (P = 0.001, r = 0.60)存在相关性。AR患者的症状评分与ECP、IL-17、IL-33无相关性。结论:AR患者血清ECP、IL-17和IL-33水平明显高于健康对照组。这表明这些标记物可用于AR的诊断和疾病监测。抑制IL-17和IL-33的分子可能被认为是一种新的治疗策略。
Evidence for eosinophil and IL-17 mediated inflammation in allergic rhinitis.
Background: The aim was to determine the level of inflammatory cytokines, eosinophil cationic protein and IgE in allergic rhinitis (AR) patients.
Subjects and methods: Blood samples were taken from 88 AR patients and 88 healthy controls (HC). Each sample was analysed for eosinophil counts by flow cytometry, IgE by ECLIA, ECP, IL-17, and IL-33 by using ELISA test.
Results: There was no significant difference between AR patients and the control group in age and gender. Levels of eosinophils, IgE, ECP, IL-17, IL-33 and the total symptom scores were significantly higher in AR patients than the HC (P = 0.0001). Serum ECP correlated with IL-17 (P = 0.041, r = 0.42), IL-33 (P = 0.0001, r = 080), and IgE levels (P = 0.017, r = 0.45) in the R patients. There was no correlation between IL-17 and IL-33. There was a correlation between symptom scores and eosinophils (P = 0.026, r = 0.52), and IgE (P = 0.001, r = 0.60) in the patients. No correlation was observed between symptom scores and ECP, IL-17, and IL-33 in the AR patient.
Conclusions: Patients with AR have significant higher serum levels of ECP, IL-17, and IL-33 than healthy controls. This indicates that these markers could be used to in order to diagnose AR and to monitor disease. Inhibitory molecules to IL-17 and IL-33 may be considered as novel treatment strategies.
期刊介绍：
Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.
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