母乳和早产儿肠道微生物群:一种预防坏死性小肠结肠炎的方法。

Q1 Medicine
Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-03-31 DOI:10.1159/000505337
W Allan Walker, Di Meng
{"title":"母乳和早产儿肠道微生物群:一种预防坏死性小肠结肠炎的方法。","authors":"W Allan Walker,&nbsp;Di Meng","doi":"10.1159/000505337","DOIUrl":null,"url":null,"abstract":"<p><p>Necrotizing enterocolitis (NEC) is a devastating inflammatory condition of the intestine, which affects premature infants and causes untold damage. Its pathogenesis has to do with how colonizing bacteria interact with the immature newborn intestine. An immature innate immune response with increased TLR-4 on the cell surface and increased signaling molecules, such as NF-κB, can cause excessive inflammation. This is in conjunction with a decrease in the appearance of regulatory molecules which effect the control of innate responses. This condition is so devastating that it must be prevented and not treated. Fortunately, breast milk and probiotics can affect the condition leading to reduced inflammation. How does this effect work? We have shown that breast milk tryptophan and Bifidobacterium infantis result in a metabolite (indole-3-lactic acid) response, which is anti-inflammatory via inhibition of the aryl hydrocarbon receptor transcription factor which stimulates an IL-8 response. We have also shown that breast milk complex carbohydrates interacting with Bacteroides fragilis can cause short-chain fatty acids which exert anti-inflammatory effects on the newborn intestine. These breast milk metabolites could help prevent NEC if shown to be effective clinically.</p>","PeriodicalId":18986,"journal":{"name":"Nestle Nutrition Institute workshop series","volume":"94 ","pages":"103-112"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000505337","citationCount":"9","resultStr":"{\"title\":\"Breast Milk and Microbiota in the Premature Gut: A Method of Preventing Necrotizing Enterocolitis.\",\"authors\":\"W Allan Walker,&nbsp;Di Meng\",\"doi\":\"10.1159/000505337\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Necrotizing enterocolitis (NEC) is a devastating inflammatory condition of the intestine, which affects premature infants and causes untold damage. Its pathogenesis has to do with how colonizing bacteria interact with the immature newborn intestine. An immature innate immune response with increased TLR-4 on the cell surface and increased signaling molecules, such as NF-κB, can cause excessive inflammation. This is in conjunction with a decrease in the appearance of regulatory molecules which effect the control of innate responses. This condition is so devastating that it must be prevented and not treated. Fortunately, breast milk and probiotics can affect the condition leading to reduced inflammation. How does this effect work? We have shown that breast milk tryptophan and Bifidobacterium infantis result in a metabolite (indole-3-lactic acid) response, which is anti-inflammatory via inhibition of the aryl hydrocarbon receptor transcription factor which stimulates an IL-8 response. We have also shown that breast milk complex carbohydrates interacting with Bacteroides fragilis can cause short-chain fatty acids which exert anti-inflammatory effects on the newborn intestine. These breast milk metabolites could help prevent NEC if shown to be effective clinically.</p>\",\"PeriodicalId\":18986,\"journal\":{\"name\":\"Nestle Nutrition Institute workshop series\",\"volume\":\"94 \",\"pages\":\"103-112\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000505337\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nestle Nutrition Institute workshop series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000505337\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/3/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nestle Nutrition Institute workshop series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000505337","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/3/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 9

摘要

坏死性小肠结肠炎(NEC)是一种破坏性的肠道炎症,影响早产儿并造成无法估量的损害。它的发病机制与定植细菌如何与未成熟的新生儿肠道相互作用有关。细胞表面TLR-4增加和信号分子如NF-κB增加的不成熟先天免疫反应可引起过度炎症。这与影响先天反应控制的调节分子的出现减少有关。这种情况是毁灭性的,必须预防而不是治疗。幸运的是,母乳和益生菌可以减少炎症。这种效应是如何起作用的?我们已经证明母乳色氨酸和婴儿双歧杆菌导致代谢物(吲哚-3-乳酸)反应,这是通过抑制芳烃受体转录因子刺激IL-8反应的抗炎作用。我们还表明,母乳中的复合碳水化合物与脆弱拟杆菌相互作用会产生短链脂肪酸,对新生儿的肠道产生抗炎作用。如果临床证明这些母乳代谢物有效,可能有助于预防NEC。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breast Milk and Microbiota in the Premature Gut: A Method of Preventing Necrotizing Enterocolitis.

Necrotizing enterocolitis (NEC) is a devastating inflammatory condition of the intestine, which affects premature infants and causes untold damage. Its pathogenesis has to do with how colonizing bacteria interact with the immature newborn intestine. An immature innate immune response with increased TLR-4 on the cell surface and increased signaling molecules, such as NF-κB, can cause excessive inflammation. This is in conjunction with a decrease in the appearance of regulatory molecules which effect the control of innate responses. This condition is so devastating that it must be prevented and not treated. Fortunately, breast milk and probiotics can affect the condition leading to reduced inflammation. How does this effect work? We have shown that breast milk tryptophan and Bifidobacterium infantis result in a metabolite (indole-3-lactic acid) response, which is anti-inflammatory via inhibition of the aryl hydrocarbon receptor transcription factor which stimulates an IL-8 response. We have also shown that breast milk complex carbohydrates interacting with Bacteroides fragilis can cause short-chain fatty acids which exert anti-inflammatory effects on the newborn intestine. These breast milk metabolites could help prevent NEC if shown to be effective clinically.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nestle Nutrition Institute workshop series
Nestle Nutrition Institute workshop series Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.30
自引率
0.00%
发文量
22
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信