母乳喂养:一种影响短期和长期免疫健康的个性化药物。

Q1 Medicine
Nestle Nutrition Institute workshop series Pub Date : 2020-01-01 Epub Date: 2020-03-27 DOI:10.1159/000505578
Valérie Verhasselt
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引用次数: 3

摘要

新生儿免疫系统有其自身的反应性、限制和挑战,这与成人有很大的不同。母乳很可能是早期最佳免疫功能和长期免疫健康的免疫系统印记的关键需求。在这里,我们将重点介绍母乳如何填补发育中的免疫系统的需求和空白,从而代表了预防传染病的不可战胜的方式。我们将进一步关注母乳中我们广泛研究并发现的积极影响免疫轨迹和长期免疫健康的一些因素。更具体地说,我们将回顾母乳中过敏原的存在以及母乳中的辅助因子如TGF-β、维生素A和免疫球蛋白如何影响早期黏膜免疫,并对过敏性疾病的易感性产生长期影响。我们将看到,根据母乳中过敏原的含量和性质以及免疫调节剂的存在,可以观察到非常不同的结果,从保护到增加过敏风险。我们开始破译新生儿免疫系统最佳运作的具体要求。我们正在发现母乳如何满足这些需求,并从生命早期开始引导免疫轨迹。回答这些问题将为婴儿提供针对这一特定生命阶段的预防和治疗方法,并将确保长期的免疫健康。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breastfeeding, a Personalized Medicine with Influence on Short- and Long-Term Immune Health.

The neonatal immune system has its own reactivity, constraints, and challenges, which profoundly differ from the adult. Breast milk is most probably a key requirement both for optimal immune function in early life and for imprinting of the immune system for long-term immune health. Here, we will highlight how breast milk fills the needs and the gaps of the developing immune system and thereby represents the unbeatable way to prevent infectious disease. We will further focus on some factors in breast milk that we extensively studied and found to actively influence the immune trajectory and long-term immune health. More specifically, we will review how the presence of allergens in breast milk together with maternal milk cofactors such as TGF-β, vitamin A, and immunoglobulins influence mucosal immunity in early life with long-term effects on allergic disease susceptibility. We will see that, depending on the content and the nature of allergens in breast milk as well as the presence of immune modulators, very different outcomes are observed, ranging from protection to an increased allergy risk. We are starting to decipher the specific requirements for the neonatal immune system to function optimally. We are discovering how breast milk fulfills these requirements and guides immune trajectories from early life. Answering these questions will provide the infant with preventive and curative approaches that are tailored to this very specific period of life and will ensure long-term immune health.

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来源期刊
Nestle Nutrition Institute workshop series
Nestle Nutrition Institute workshop series Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.30
自引率
0.00%
发文量
22
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