{"title":"胎盘基因表达与后代气质轨迹:预测幼儿期负面情绪。","authors":"J Finik, J Buthmann, W Zhang, K Go, Y Nomura","doi":"10.1007/s10802-020-00632-9","DOIUrl":null,"url":null,"abstract":"<p><p>Exposure to prenatal stress increases offspring risk for long-term neurobehavioral impairments and psychopathology, such as Attention Deficit Hyperactivity Disorder (ADHD). Epigenetic regulation of glucocorticoid pathway genes may be a potential underlying mechanism by which maternal conditions 'program' the fetal brain for downstream vulnerabilities. The present study aims to investigate whether mRNA expression of glucocorticoid pathway genes in the placenta predict offspring negative affect during early childhood (between 6 and 24 months). Participants include 318 mother-child dyads participating in a longitudinal birth cohort study. Placental mRNA expression of glucocorticoid pathway genes (HSD11B1, HSD11B2, NR3C1, NCOR2) were profiled and negative affect traits of the offspring were measured at 6, 12, 18, and 24 months. HSD11B1 mRNA expression significantly predicted negative affect (β = -.09, SE = .04; p = .036), and Distress to Limitations trajectories (β = -.13, SE = .06; p = .016). NCOR2 mRNA expression significantly predicted Distress to Limitations (β = .43, SE = .21; p = .047), and marginally predicted Sadness trajectories (β = .39, SE = .21; p = .068). HSD11B2 and NR3C1 did not predict trajectories of Negative Affect or subscale scores. Infant negative affect traits were assessed via maternal self-report, and deviated from linearity across follow-up. mRNA expression of glucocorticoid pathway genes in the placenta may be a potentially novel tool for early identification of infants at greater risk for elevated negative affect. 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引用次数: 3
摘要
暴露在产前压力下会增加后代长期神经行为障碍和精神病理的风险,如注意缺陷多动障碍(ADHD)。糖皮质激素通路基因的表观遗传调控可能是母体条件“编程”胎儿大脑下游脆弱性的潜在潜在机制。本研究旨在探讨胎盘中糖皮质激素通路基因的mRNA表达是否能预测幼儿期(6 - 24个月)子代的负面影响。参与者包括318对参与纵向出生队列研究的母子二人组。在6、12、18和24月龄时,分析胎盘糖皮质激素通路基因(HSD11B1、HSD11B2、NR3C1、NCOR2)的mRNA表达,并测定后代的负面影响性状。HSD11B1 mRNA表达显著预测负面情绪(β = -)。09, se = .04;p = .036),以及极限困境轨迹(β = -。13, se = .06;p = .016)。NCOR2 mRNA表达量与窘迫程度有显著相关性(β =。43, se = .21;p = .047),并且边际预测悲伤轨迹(β =。39, se = .21;p = .068)。HSD11B2和NR3C1不能预测消极情绪或分量表得分的轨迹。通过母亲自我报告评估婴儿负面情绪特征,并在随访中偏离线性。胎盘中糖皮质激素通路基因的mRNA表达可能是一种潜在的新工具,可用于早期识别具有较高负面影响风险的婴儿。需要进一步的研究来验证糖皮质激素通路基因mRNA表达在胎盘中的实用性。
Placental Gene Expression and Offspring Temperament Trajectories: Predicting Negative Affect in Early Childhood.
Exposure to prenatal stress increases offspring risk for long-term neurobehavioral impairments and psychopathology, such as Attention Deficit Hyperactivity Disorder (ADHD). Epigenetic regulation of glucocorticoid pathway genes may be a potential underlying mechanism by which maternal conditions 'program' the fetal brain for downstream vulnerabilities. The present study aims to investigate whether mRNA expression of glucocorticoid pathway genes in the placenta predict offspring negative affect during early childhood (between 6 and 24 months). Participants include 318 mother-child dyads participating in a longitudinal birth cohort study. Placental mRNA expression of glucocorticoid pathway genes (HSD11B1, HSD11B2, NR3C1, NCOR2) were profiled and negative affect traits of the offspring were measured at 6, 12, 18, and 24 months. HSD11B1 mRNA expression significantly predicted negative affect (β = -.09, SE = .04; p = .036), and Distress to Limitations trajectories (β = -.13, SE = .06; p = .016). NCOR2 mRNA expression significantly predicted Distress to Limitations (β = .43, SE = .21; p = .047), and marginally predicted Sadness trajectories (β = .39, SE = .21; p = .068). HSD11B2 and NR3C1 did not predict trajectories of Negative Affect or subscale scores. Infant negative affect traits were assessed via maternal self-report, and deviated from linearity across follow-up. mRNA expression of glucocorticoid pathway genes in the placenta may be a potentially novel tool for early identification of infants at greater risk for elevated negative affect. Further study is needed to validate the utility of mRNA expression of glucocorticoid pathway genes in the placenta.
期刊介绍:
Research on Child and Adolescent Psychopathology brings together the latest innovative research that advances knowledge of psychopathology from infancy through adolescence. The journal publishes studies that have a strong theoretical framework and use a diversity of methods, with an emphasis on empirical studies of the major forms of psychopathology found in childhood disorders (e.g., disruptive behavior disorders, depression, anxiety, and autism spectrum disorder). Studies focus on the epidemiology, etiology, assessment, treatment, prognosis, and developmental course of these forms of psychopathology. Studies highlighting risk and protective factors; the ecology and correlates of children''s emotional, social, and behavior problems; and advances in prevention and treatment are featured.
Research on Child and Adolescent Psychopathology is the official journal of the International Society for Research in Child and Adolescent Psychopathology (ISRCAP), a multidisciplinary scientific society.