DNA双链断裂的检查点反应。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2020-06-20 Epub Date: 2020-03-16 DOI:10.1146/annurev-biochem-011520-104722

David P Waterman, James E Haber, Marcus B Smolka

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引用次数: 0

摘要

细胞在每个细胞周期中都会面临DNA损伤。最有害的DNA损伤类型是DNA双链断裂(DSBs)，如果不修复，可能导致细胞死亡，如果修复不当，可能导致癌症。在DNA dsb的反应中，细胞激活复杂的DNA损伤检查点(DDC)反应，阻止细胞周期，重新编程基因表达，并动员DNA修复因子来防止未修复和断裂染色体的遗传。在这里，我们研究了DNA dsb在出芽酵母模型系统和哺乳动物中诱导的DDC。

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Checkpoint Responses to DNA Double-Strand Breaks.

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.