海胆早期发育的模拟描述了定向细胞分裂在桑葚胚向囊胚过渡中的作用

IF 2.6 Q2 Medicine
Lawrence Bodenstein
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引用次数: 6

摘要

海胆桑葚胚向囊胚的转变长期以来被认为需要定向细胞分裂和囊胚粘附在包膜透明层上。在计算机模拟模型中,受表面分裂规则约束的细胞分裂足以影响形态转变。透明膜作为增强剂,但不是必需的。该模型与直接发育物种的微粒分裂方向和开放囊胚一致。表面分裂规律先于表面细胞的明显上皮形成,并组织发育中的上皮。它是后生动物早期发育的普遍特征,非棘刺类卵裂模式的模拟支持其在后生动物中的作用。平面划分规则只需要局部线索,细胞不需要参考全局位置信息或胚胎轴。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simulations of sea urchin early development delineate the role of oriented cell division in the morula-to-blastula transition

The sea urchin morula to blastula transition has long been thought to require oriented cell divisions and blastomere adherence to the enveloping hyaline layer. In a computer simulation model, cell divisions constrained by a surface plane division rule are adequate to effect morphological transition. The hyaline membrane acts as an enhancer but is not essential. The model is consistent with the orientation of micromere divisions and the open blastulae of direct developing species. The surface plane division rule precedes overt epithelization of surface cells and acts to organize the developing epithelium. It is a universal feature of early metazoan development and simulations of non-echinoid cleavage patterns support its role throughout Metazoa. The surface plane division rule requires only local cues and cells need not reference global positional information or embryonic axes.

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来源期刊
Mechanisms of Development
Mechanisms of Development 生物-发育生物学
CiteScore
3.60
自引率
0.00%
发文量
0
审稿时长
12.4 weeks
期刊介绍: Mechanisms of Development is an international journal covering the areas of cell biology and developmental biology. In addition to publishing work at the interphase of these two disciplines, we also publish work that is purely cell biology as well as classical developmental biology. Mechanisms of Development will consider papers in any area of cell biology or developmental biology, in any model system like animals and plants, using a variety of approaches, such as cellular, biomechanical, molecular, quantitative, computational and theoretical biology. Areas of particular interest include: Cell and tissue morphogenesis Cell adhesion and migration Cell shape and polarity Biomechanics Theoretical modelling of cell and developmental biology Quantitative biology Stem cell biology Cell differentiation Cell proliferation and cell death Evo-Devo Membrane traffic Metabolic regulation Organ and organoid development Regeneration Mechanisms of Development does not publish descriptive studies of gene expression patterns and molecular screens; for submission of such studies see Gene Expression Patterns.
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