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引用次数: 0
摘要
来自流行病学研究和动物模型的越来越多的证据表明，暴露于环境因素与表观遗传标记（尤其是 DNA 甲基化）的变化有关。这些表观遗传变化可能导致分子过程和功能失调，并介导环境暴露对复杂疾病的影响。然而，导致暴露后表观遗传变化的详细分子事件仍不清楚。在此，我们回顾了支持十-十一易位 1（TET1）在介导这些过程中发挥关键作用的新证据。针对 TET1 及其相关途径可能具有治疗潜力，可减轻环境暴露的负面影响，预防和治疗与暴露相关的疾病。
The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures.
Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases.
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