了解酪氨酸在糖原蛋白†中的作用

IF 3.743 Q2 Biochemistry, Genetics and Molecular Biology

Molecular BioSystems Pub Date : 2017-06-30 DOI:10.1039/C7MB00293A

Ander Camiruaga, Imanol Usabiaga, Aran Insausti, Emilio J. Cocinero, Iker León and José A. Fernández

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引用次数: 5

摘要

我们探索了在糖原合成过程中酪氨酸作为第一个葡萄糖分子的对接氨基酸的分子基础。红外光谱表明，芳香环作为诱饵，通过引诱不需要的分子靠近芳香环，保持下一个葡萄糖单元必须结合的位置。只有α-/β-葡萄糖对O3H和O4H基团表现出特殊的亲和力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Understanding the role of tyrosine in glycogenin†

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Understanding the role of tyrosine in glycogenin†

We explored the molecular basis of tyrosine as the docking amino acid for the first glucose molecule during the synthesis of glycogen. The IR spectra show that the aromatic ring acts as bait to keep the position where the next glucose unit has to bind clear, by luring non-desirable molecules towards the aromatic ring. Only, α-/β-glucose shows particular affinity for the O3H and O4H moieties.

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来源期刊

Molecular BioSystems 生物-生化与分子生物学

CiteScore

2.94

自引率

0.00%

发文量

审稿时长

2.6 months

期刊介绍： Molecular Omics publishes molecular level experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. We will also welcome multidisciplinary papers presenting studies combining different types of omics, or the interface of omics and other fields such as systems biology or chemical biology.