临床药理学在耐多药恶性疟原虫化疗中的作用。

IF 2.3 4区医学 Q3 PHARMACOLOGY & PHARMACY

Journal of clinical pharmacology Pub Date : 2020-07-01 Epub Date: 2020-02-27 DOI:10.1002/jcph.1589

Juntra Karbwang, Kesara Na-Bangchang

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引用次数: 3

摘要

由于耐多药恶性疟原虫的出现和传播，疟疾仍然是全球主要的公共卫生问题之一。近年来，临床药理学对抗疟药物的最佳给药方案作出了重大贡献。药物计量学建模和模拟的应用有助于准确表征药代动力学-药效学关系，并优化现有抗疟药物的剂量方案，包括不同人群中耐多药恶性疟原虫的新抗疟候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Clinical Pharmacology in Chemotherapy of Multidrug-Resistant Plasmodium falciparum.

Malaria remains one of the major global public health problems due to the emergence and spread of multidrug-resistant Plasmodium falciparum. In recent years, clinical pharmacology has significantly contributed to the optimal dosing regimens of antimalarial drugs. The application of pharmacometric modeling and simulation has assisted in the accurate characterization of pharmacokinetic-pharmacodynamic relationships and the optimization of the dosage regimens of existing antimalarial drugs, including new antimalarial candidates for multidrug-resistant P falciparum in different populations.

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来源期刊

Journal of clinical pharmacology 医学-药学

CiteScore

5.10

自引率

3.40%

发文量

176

审稿时长

2 months

期刊介绍： The Journal of Clinical Pharmacology (JCP) is a Human Pharmacology journal designed to provide physicians, pharmacists, research scientists, regulatory scientists, drug developers and academic colleagues a forum to present research in all aspects of Clinical Pharmacology. This includes original research in pharmacokinetics, pharmacogenetics/pharmacogenomics, pharmacometrics, physiologic based pharmacokinetic modeling, drug interactions, therapeutic drug monitoring, regulatory sciences (including unique methods of data analysis), special population studies, drug development, pharmacovigilance, womens’ health, pediatric pharmacology, and pharmacodynamics. Additionally, JCP publishes review articles, commentaries and educational manuscripts. The Journal also serves as an instrument to disseminate Public Policy statements from the American College of Clinical Pharmacology.