{"title":"阿片类药物维持治疗中阿片类药物和多种药物的使用。","authors":"Siv-Elin Leirvaag Carlsen, Linn-Heidi Lunde, Torbjørn Torsheim","doi":"10.2147/SAR.S221618","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Opioid maintenance treatment reduces a person's use of heroin. However, frequent substance use in treatment is a problem.</p><p><strong>Aim: </strong>To examine the association between opioid maintenance treatment and opioid/polydrug use, and whether social factors, adverse experiences, social resources, and quality of life are associated with opioid/polydrug use during the first 12 months in treatment.</p><p><strong>Patients and methods: </strong>Forty-seven participants from treatment units in Bergen, Norway participated in five waves of data collection. Every third month, a structured face-to-face interview collected self-reported data on sociodemographic characteristics, opioid/polydrug use, participants' social resources or adverse experiences, and quality of life. Data were collected as part of KVARUS, the National Quality Register for Substance Abuse Treatment. A multilevel binary logistic regression analysis was conducted to examine the association of opioid/polydrug use and time in current treatment. The analysis included regressions of opioid/polydrug use on time-invariant baseline adverse experiences and social resources, and time-varying reports of quality of life.</p><p><strong>Results: </strong>There was a significant negative association between time in treatment and use of opioids, <i>b</i> =-0.89, <i>SE</i> = 0.19, <i>p</i> = <0.01. Furthermore, a negative association of age at substance use on polydrug use was found, <i>b</i> =-0.40, <i>SE</i> =0.19, <i>p</i> = 0.03. A higher overall quality of life was significantly associated with lower odds of opioid use during opioid maintenance treatment, <i>b</i> = -0.62, <i>SE</i> = 0.23, <i>p</i> = < 0.01. Social dimensions, participants' adverse experiences, and social resources were not associated with polydrug or opioid use.</p><p><strong>Conclusion: </strong>Opioid maintenance treatment is associated with lowered opioid use, but to a lesser degree with polydrug use. Our findings add quality of life as an important factor that should be given particular attention because it can offer insight to aspects that can affect the patients' opioid use.</p>","PeriodicalId":22060,"journal":{"name":"Substance Abuse and Rehabilitation","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/SAR.S221618","citationCount":"1","resultStr":"{\"title\":\"Opioid and Polydrug Use Among Patients in Opioid Maintenance Treatment.\",\"authors\":\"Siv-Elin Leirvaag Carlsen, Linn-Heidi Lunde, Torbjørn Torsheim\",\"doi\":\"10.2147/SAR.S221618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Opioid maintenance treatment reduces a person's use of heroin. However, frequent substance use in treatment is a problem.</p><p><strong>Aim: </strong>To examine the association between opioid maintenance treatment and opioid/polydrug use, and whether social factors, adverse experiences, social resources, and quality of life are associated with opioid/polydrug use during the first 12 months in treatment.</p><p><strong>Patients and methods: </strong>Forty-seven participants from treatment units in Bergen, Norway participated in five waves of data collection. Every third month, a structured face-to-face interview collected self-reported data on sociodemographic characteristics, opioid/polydrug use, participants' social resources or adverse experiences, and quality of life. Data were collected as part of KVARUS, the National Quality Register for Substance Abuse Treatment. A multilevel binary logistic regression analysis was conducted to examine the association of opioid/polydrug use and time in current treatment. The analysis included regressions of opioid/polydrug use on time-invariant baseline adverse experiences and social resources, and time-varying reports of quality of life.</p><p><strong>Results: </strong>There was a significant negative association between time in treatment and use of opioids, <i>b</i> =-0.89, <i>SE</i> = 0.19, <i>p</i> = <0.01. Furthermore, a negative association of age at substance use on polydrug use was found, <i>b</i> =-0.40, <i>SE</i> =0.19, <i>p</i> = 0.03. A higher overall quality of life was significantly associated with lower odds of opioid use during opioid maintenance treatment, <i>b</i> = -0.62, <i>SE</i> = 0.23, <i>p</i> = < 0.01. Social dimensions, participants' adverse experiences, and social resources were not associated with polydrug or opioid use.</p><p><strong>Conclusion: </strong>Opioid maintenance treatment is associated with lowered opioid use, but to a lesser degree with polydrug use. Our findings add quality of life as an important factor that should be given particular attention because it can offer insight to aspects that can affect the patients' opioid use.</p>\",\"PeriodicalId\":22060,\"journal\":{\"name\":\"Substance Abuse and Rehabilitation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2020-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2147/SAR.S221618\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Substance Abuse and Rehabilitation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2147/SAR.S221618\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Substance Abuse and Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2147/SAR.S221618","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 1
摘要
目的:阿片类药物维持治疗减少一个人对海洛因的使用。然而，在治疗中频繁使用药物是一个问题。目的:探讨阿片类药物维持治疗与阿片类/多种药物使用之间的关系，以及治疗前12个月的社会因素、不良经历、社会资源和生活质量是否与阿片类/多种药物使用有关。患者和方法:来自挪威卑尔根治疗单位的47名参与者参与了五波数据收集。每三个月进行一次结构化的面对面访谈，收集有关社会人口学特征、阿片类药物/多种药物使用、参与者的社会资源或不良经历以及生活质量的自我报告数据。数据是作为KVARUS(国家药物滥用治疗质量登记)的一部分收集的。采用多水平二元logistic回归分析来检验当前治疗中阿片类药物/多种药物使用与时间的关系。分析包括阿片类药物/多种药物使用对时不变基线不良经历和社会资源的回归，以及时变生活质量报告。结果:治疗时间与阿片类药物使用呈显著负相关，b =-0.89, SE =0.19, p = b =-0.40, SE =0.19, p = 0.03。在阿片类药物维持治疗期间，较高的总体生活质量与较低的阿片类药物使用几率显著相关，b = -0.62, SE = 0.23, p = < 0.01。社会维度、参与者的不良经历和社会资源与多种药物或阿片类药物的使用无关。结论:阿片类药物维持治疗与阿片类药物使用减少有关，但与多种药物使用的程度较低。我们的研究结果增加了生活质量作为一个重要因素，应该给予特别关注，因为它可以提供对可能影响患者阿片类药物使用的方面的见解。
Opioid and Polydrug Use Among Patients in Opioid Maintenance Treatment.
Purpose: Opioid maintenance treatment reduces a person's use of heroin. However, frequent substance use in treatment is a problem.
Aim: To examine the association between opioid maintenance treatment and opioid/polydrug use, and whether social factors, adverse experiences, social resources, and quality of life are associated with opioid/polydrug use during the first 12 months in treatment.
Patients and methods: Forty-seven participants from treatment units in Bergen, Norway participated in five waves of data collection. Every third month, a structured face-to-face interview collected self-reported data on sociodemographic characteristics, opioid/polydrug use, participants' social resources or adverse experiences, and quality of life. Data were collected as part of KVARUS, the National Quality Register for Substance Abuse Treatment. A multilevel binary logistic regression analysis was conducted to examine the association of opioid/polydrug use and time in current treatment. The analysis included regressions of opioid/polydrug use on time-invariant baseline adverse experiences and social resources, and time-varying reports of quality of life.
Results: There was a significant negative association between time in treatment and use of opioids, b =-0.89, SE = 0.19, p = <0.01. Furthermore, a negative association of age at substance use on polydrug use was found, b =-0.40, SE =0.19, p = 0.03. A higher overall quality of life was significantly associated with lower odds of opioid use during opioid maintenance treatment, b = -0.62, SE = 0.23, p = < 0.01. Social dimensions, participants' adverse experiences, and social resources were not associated with polydrug or opioid use.
Conclusion: Opioid maintenance treatment is associated with lowered opioid use, but to a lesser degree with polydrug use. Our findings add quality of life as an important factor that should be given particular attention because it can offer insight to aspects that can affect the patients' opioid use.
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