基质玻璃蛋白(MGP)基因遗传多态性与冠状动脉疾病和血清MGP水平的关系

Balkan journal of medical genetics : BJMG Pub Date : 2019-12-21 eCollection Date: 2019-12-01 DOI:10.2478/bjmg-2019-0020
S Karsli-Ceppioglu, S Yazar, Y Keskin, M Karaca, N E Luleci, T Yurdun
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引用次数: 1

摘要

基质玻璃蛋白(Matrix Gla protein, MGP)是抑制血管壁和软骨钙化的重要调节蛋白。MGP基因多态性被怀疑通过改变相关基因表达和血清MGP水平来增加细胞外钙化的风险。本研究的目的是检测MGP基因rs4236 (Thr83-Ala)、rs12304 (Glu60-X)和rs1800802 (T138-C)多态性与冠状动脉钙化的相关性。对168例冠状动脉造影患者的血清MGP水平进行分析,并对MGP基因多态性进行基因分型分析。结果表明,血清MGP水平与MGP基因rs4236和rs1800802多态性与冠状动脉疾病(CAD)的发生显著相关。MGP基因多态性和血清MGP水平的等位基因分布分别与CAD的存在无显著相关性。我们的研究结果显示,CAD患者的血清MGP水平与rs4236和rs1800802多态性相关,但血清MGP水平本身并不能直接反映CAD的风险。在心血管疾病中,应重视MGP基因变异在动脉钙化形成和进展中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of Genetic Polymorphisms in the <i>Matrix Gla Protein (MGP)</i> Gene with Coronary Artery Disease and Serum MGP Levels.

Association of Genetic Polymorphisms in the <i>Matrix Gla Protein (MGP)</i> Gene with Coronary Artery Disease and Serum MGP Levels.

Association of Genetic Polymorphisms in the <i>Matrix Gla Protein (MGP)</i> Gene with Coronary Artery Disease and Serum MGP Levels.

Association of Genetic Polymorphisms in the Matrix Gla Protein (MGP) Gene with Coronary Artery Disease and Serum MGP Levels.

Matrix Gla protein (MGP) is an important regulatory protein for inhibition of calcification in the vessel wall and cartilage. The MGP gene polymorphisms are suspected to increase the risk of extracellular calcification through altering the related gene expression and serum MGP levels. The goal of this study was to examine the correlation between rs4236 (Thr83-Ala), rs12304 (Glu60-X) and rs1800802 (T138-C) polymorphisms of the MGP gene and coronary artery calcification. Serum MGP levels of 168 subjects who had undergone coronary angiography were analyzed along with genotyping of MGP gene polymorphisms. The results indicated that serum MGP levels were significantly associated with rs4236 and rs1800802 polymorphisms of the MGP gene with the occurrence of coronary artery diseases (CAD). Allelic distributions of MGP gene polymorphisms and serum MGP levels, respectively, were not significantly interconnected with the presence of CAD. Our results revealed that serum MGP levels of CAD patients show association with rs4236 and rs1800802 polymorphisms, but serum MGP levels alone do not directly reflect the risk of CAD. The role of MGP genetic variants on formation and progression of arterial calcification should be regarded in cardiovascular diseases.

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