早发性st段抬高型心肌梗死载脂蛋白A的测定。

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiovascular Endocrinology & Metabolism Pub Date : 2019-11-13 eCollection Date: 2019-12-01 DOI:10.1097/XCE.0000000000000183
Ameen Mosa Mohammad, Ahmed Hasan Yousif, Bayar Ahmed Qasim, Joma Aziz Joma, Saad Younis Saeed
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引用次数: 0

摘要

目的:载脂蛋白A在早发性st段抬高型心肌梗死中的作用尚不清楚。本研究旨在评估早发性急性st段抬高型心肌梗死患者的载脂蛋白A水平,并探讨其与主要传统心血管危险因素的相关性。方法:对50例年龄小于50岁的此类患者和40例年龄、性别匹配的健康对照者进行基线人口统计学、临床特征和心血管危险因素的研究。对所有受试者的载脂蛋白A进行估计。结果:患者平均年龄43.37±5.85岁。与对照组相比,病例间载脂蛋白A水平无显著降低(P = 0.52)。在男性、吸烟人群和血脂异常人群中均较低(P < 0.05)。考虑载脂蛋白A为依赖因素,经线性回归分析,早发性st段抬高型心肌梗死与男性显著相关,与血脂异常显著相关(P < 0.001, P < 0.030)。结论:载脂蛋白A水平降低与早发性st段抬高型心肌梗死的常规危险因素显著相关。这种载脂蛋白A尤其发生在具有传统心血管危险因素聚集性的年轻患者中,应该成为治疗目标。在st段抬高型心肌梗死中,该载脂蛋白的诊断和预后指标有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimation of apolipoprotein A in early onset ST-segment elevation myocardial infarction.

Aims: The role of apolipoprotein A in early onset ST-segment elevation myocardial infarction is not clear. This study sought to assess the apolipoprotein A in cohort of patients diagnosed with early onset acute ST-segment elevation myocardial infarction and to corelate it with major traditional cardiovascular risk factors.

Methods: A total of 50 such patients and 40 age and sex-matched healthy controls, both aged less than 50 years with their baseline demographic, clinical characteristics and cardiovascular risk factors were studied. Apolipoprotein A was estimated for all enrollees.

Results: The mean age of cases was 43.37 ± 5.85 years. The levels of apolipoprotein A among cases were not significantly lower compared to controls (P = 0.52). They were lower among the male, current smokers and the dyslipidemia (P's < 0.05). Considering the apolipoprotein A as the dependent factor, the early onset ST-segment elevation myocardial infarction was associated significantly with the male and the dyslipidemia in linear regression (P < 0.001 and 0.030), respectively.

Conclusion: Lower levels of apolipoprotein A are significantly related to conventional risk factors in early onset ST-segment elevation myocardial infarction. This apolipoprotein A that particularly develops in young patients with clustering of traditional cardiovascular risk factors should be targeted. Further studies are warranted to determine the diagnostic and prognostic indicators of this apolipoprotein in ST-segment elevation myocardial infarction.

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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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