神经性厌食症的低骨密度:治疗和挑战。

IF 0.8 Q4 ENDOCRINOLOGY & METABOLISM
Pouneh K Fazeli
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引用次数: 14

摘要

神经性厌食症是一种主要影响妇女的精神疾病,其特点是自我诱导的饥饿和由此产生的低体重状态。在饥饿期间,一些激素适应——包括下丘脑闭经和生长激素抵抗——允许在营养摄入减少期间减少能量消耗,但这些同样的适应也导致了与慢性饥饿相关的医学并发症,包括低骨量。几乎90%患有神经性厌食症的女性骨密度(BMD)值比健康女性骨密度峰值的平均值低一个标准差以上,这种疾病与骨折风险显著增加有关。虽然已经研究了多种治疗神经性厌食症低骨量的方法,但目前还没有批准的治疗方法,也没有多少有希望的长期治疗选择。这篇综述将概述神经性厌食症低骨量的介质,讨论已经研究的治疗这种疾病的低骨密度的方法,并强调仍然存在的重要挑战,包括青少年神经性厌食症的骨模型与成人的差异,需要在这两个人群中分别测试潜在的治疗方法,以及治疗这种疾病骨质流失的长期治疗策略的缺乏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low bone mineral density in anorexia nervosa: Treatments and challenges.

Anorexia nervosa, a psychiatric disease predominantly affecting women, is characterized by self- induced starvation and a resultant low-weight state. During starvation, a number of hormonal adaptations - including hypothalamic amenorrhea and growth hormone resistance - allow for decreased energy expenditure during periods of decreased nutrient intake, but these very same adaptations also contribute to the medical complications associated with chronic starvation, including low bone mass. Almost 90% of women with anorexia nervosa have bone mineral density (BMD) values more than one-standard deviation below the mean of healthy women at peak bone mineral density and this disease is associated with a significantly increased risk of fracture. Although multiple therapies have been studied for the treatment of low bone mass in anorexia nervosa, there are currently no approved therapies and few promising long-term therapeutic options. This review will outline the mediators of low bone mass in anorexia nervosa, discuss therapies that have been studied for the treatment of low BMD in this disorder, and highlight the important challenges that remain, including the differences in bone modeling in adolescents with anorexia nervosa as compared to adults, necessitating that potential therapies be tested in these two populations separately, and the paucity of long-term therapeutic strategies for treating bone loss in this disorder.

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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
2
期刊介绍: Clinical Reviews in Bone and Mineral Metabolism is an international review journal aimed at integrating new information from both basic and clinical science into the context of clinical practice in the wide field of Bone and Mineral Metabolism. Although one purpose of the journal is to deal with the well-known classical aspects of bone and mineral physiology, the journal’s unique character is to highlight information about the advancing field of molecular medicine, which now finds linkages between this classical field and disease states that in the past were considered distinct. For example, cardiovascular disease and osteoporosis share many biochemical pathways. New molecular tools show common pathways with bone physiology and obesity, diabetes mellitus, and energy metabolism. The focus on the novel is a major aspect of this journal’s purpose. The rapid developments in the field needs to be represented in a comprehensive way in order to keep students, clinicians and researchers up-to date. In order to assure that all latest developments are covered, the journal publishes, not only, unsolicited reviews, but also invited reviews on most important topics as well.
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