儿童急性淋巴细胞白血病脑脊液浸润的多重生物标志物评价。

International Journal of Hematologic Oncology Pub Date : 2019-08-12 DOI:10.2217/ijh-2019-0008

Neveen L Mikhael, Myriam Abo Seif H Gendi, Hoda Hassab, Elshaymaa A Megahed

{"title":"儿童急性淋巴细胞白血病脑脊液浸润的多重生物标志物评价。","authors":"Neveen L Mikhael, Myriam Abo Seif H Gendi, Hoda Hassab, Elshaymaa A Megahed","doi":"10.2217/ijh-2019-0008","DOIUrl":null,"url":null,"abstract":"Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.","PeriodicalId":14166,"journal":{"name":"International Journal of Hematologic Oncology","volume":"8 3","pages":"IJH22"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/ijh-2019-0008","citationCount":"3","resultStr":"{\"title\":\"Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia.\",\"authors\":\"Neveen L Mikhael, Myriam Abo Seif H Gendi, Hoda Hassab, Elshaymaa A Megahed\",\"doi\":\"10.2217/ijh-2019-0008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.\",\"PeriodicalId\":14166,\"journal\":{\"name\":\"International Journal of Hematologic Oncology\",\"volume\":\"8 3\",\"pages\":\"IJH22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2217/ijh-2019-0008\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hematologic Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2217/ijh-2019-0008\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hematologic Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/ijh-2019-0008","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

摘要

急性淋巴细胞白血病(ALL)是一种非常常见的儿童恶性肿瘤，具有很高的生存率。治疗过程根据中枢神经系统(CNS)疾病的发生而调整。目的:探讨血清和脑脊液中基质金属蛋白酶9、CCL-2、sVCAM-1、IFN-γ和诱导蛋白10等5种生物标志物与中枢神经系统浸润的关系。方法:对64例ALL患儿和20例对照组进行研究。采用Luminex技术检测多种细胞因子(基质金属蛋白酶9、CCL-2、sVCAM-1、IFN-γ和诱导蛋白10)。结果:在发生中枢神经系统白血病的患者中，sMMP-9显著升高，sCCL2显著降低。结论:儿童ALL诊断时血清多重参数可预测中枢神经系统白血病的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia.

查看原文本刊更多论文

Evaluation of multiplexed biomarkers in assessment of CSF infiltration in pediatric acute lymphoblastic leukemia.

Acute lymphoblastic leukemia (ALL) is a very common pediatric malignancy with high survival rates. The course of treatment is modified according to the occurrence of central nervous system (CNS) disease. Aim: To relate serum and cerebrospinal fluid levels of five biomarkers (matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10) at diagnosis to the development of CNS infiltration. Methods: The present study was carried on 64 children with ALL and 20 controls. Multiplexed cytokines were measured by Luminex technology (Matrix metalloprotienase 9, CCL-2, sVCAM-1, IFN-γ and inducible protein 10). Results: Significantly higher sMMP-9 and lower sCCL2 were found in patients who developed CNS leukemia. Conclusion: Serum multiplexed parameters at diagnosis of childhood ALL may predict of development of CNS leukemia.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： International Journal of Hematologic Oncology welcomes unsolicited article proposals. Email us today to discuss the suitability of your research and our options for authors, including Accelerated Publication. Find out more about publishing open access with us here.