2岁后补充维生素D:营养委员会、德国儿科和青少年医学学会(DGKJ e.v.)和德国儿科内分泌学和糖尿病学会(DGKED e.v.)的联合立场。

IF 2.4 Q1 PEDIATRICS
Thomas Reinehr, Dirk Schnabel, Martin Wabitsch, Susanne Bechtold-Dalla Pozza, Christoph Bührer, Bettina Heidtmann, Frank Jochum, Thomas Kauth, Antje Körner, Walter Mihatsch, Christine Prell, Silvia Rudloff, Bettina Tittel, Joachim Woelfle, Klaus-Peter Zimmer, Berthold Koletzko
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引用次数: 13

摘要

背景:在观察性研究中,低维生素D血清浓度与佝偻病和其他疾病有关。由于儿童和青少年的维生素D血清浓度经常低于参考值,因此在婴儿期后是否应该补充维生素D一直存在争议。方法:通过随机对照试验(RCTs)的文献综述,分析维生素D补充剂对> 2岁儿童的影响。结果:补充维生素D可以潜在地降低流感感染的风险,改善哮喘支气管恶化;然而,它对支气管哮喘的严重程度没有影响。补充维生素D对注意缺陷/多动障碍、心力衰竭、高血压或II型糖尿病的发病率没有相关影响。补充维生素D对多发性硬化症的复发率没有影响,但对MRI检测到的新病变数量有影响。对于其他终点,缺乏随机对照试验。结论:根据现有的研究,不建议2岁以上的儿童常规补充维生素D,即使他们的血清浓度低于参考值。对于没有与钙或维生素D吸收障碍相关的危险因素和慢性疾病的儿童,不建议常规补充维生素D。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).

Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.).

Background: Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below reference values, it is debated whether vitamin D should be supplemented after infancy.

Methods: The effects of vitamin D supplementation in children > 2 years of age are analyzed based on a literature review of randomized controlled trials (RCTs).

Results: Vitamin D supplementation can potentially reduce the risk for influenza infections and improve asthma bronchiale exacerbation; however, it has no impact on asthma bronchiale severity. Vitamin D supplementation has no relevant effect on attention-deficit/hyperactivity disorders, cardiac failure, hypertension, or incidence of type II diabetes mellitus. Vitamin D supplementation has no effect on the rate of multiple sclerosis relapses, but on the number of new lesions detected by MRI. For other endpoints, RCTs are lacking.

Conclusion: Based on currently available studies, routine vitamin D supplementation is not be recommended for children aged > 2 years, even when they have serum concentrations below reference values. Routine vitamin D supplementation is not recommended in children who do not have risk factors and chronic diseases which are associated with calcium or vitamin D resorption disorders.

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