串联质谱分析与透析患者的肉碱谱分析。

4区医学 Q3 Medicine

Contributions to nephrology Pub Date : 2019-01-01 Epub Date: 2019-04-16 DOI:10.1159/000496524

Daigo Kamei, Yuiko Kamei, Nobue Tanaka, Misao Tsukada, Naoko Miwa, Norio Hanafusa, Michio Mineshima, Kosaku Nitta, Ken Tsuchiya

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引用次数: 0

摘要

背景:肉碱缺乏症是血液透析患者的常见病。因此，脂肪酸代谢和有机酸代谢异常在透析患者中也很常见。串联质谱法是儿科和新生儿医学的标准技术。然而，它可能在其他领域为估计细胞内脂肪酸代谢状态提供一个新的有力工具。摘要:串联质谱法最近揭示了肉碱谱与透析患者贫血、身体功能下降和生存率之间的关系。脂肪酸和有机酸代谢，以前只能定性评估，现在可以定量评估。关键信息:串联质谱法的应用不仅在透析领域，而且在临床医学领域也有广泛的应用前景。

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Carnitine Profile by Tandem Mass Spectrometry and Dialysis Patients.

Background: Carnitine deficiency is a common condition in hemodialysis patients. Therefore, abnormalities in fatty acid metabolism and organic acid metabolism are also common in dialysis patients. Tandem mass spectrometry is a standard technique in pediatric and neonatal medicine. However, it could be a new powerful tool in other fields for estimating the state of intracellular fatty acid metabolism.

Summary: Tandem mass spectrometry has recently revealed the relationships between carnitine profile and dialysis patients' anemia, reduced physical function, and survival rate. Fatty acid and organic acid metabolism, which could previously only be evaluated qualitatively, can now be quantitatively assessed. Key Message: The applications of tandem mass spectrometry are expected to expand not only in the field of dialysis but also in clinical medicine in general.

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来源期刊

Contributions to nephrology 医学-泌尿学与肾脏学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The speed of developments in nephrology has been fueled by the promise that new findings may improve the care of patients suffering from renal disease. Participating in these rapid advances, this series has released an exceptional number of volumes that explore problems of immediate importance for clinical nephrology. Focus ranges from discussion of innovative treatment strategies to critical evaluations of investigative methodology. The value of regularly consolidating the newest findings and theories is enhanced through the inclusion of extensive bibliographies which make each volume a reference work deserving careful study.