Renan Dal-Fabbro, Melyna Marques de Almeida, Leopoldo Cosme-Silva, Antonio H. C. Neto, Leda M. P. Salzedas, Luciano T. A. Cintra, João E. G. Filho
{"title":"慢性饮酒改变根尖牙周炎大鼠的血液标志物和骨密度","authors":"Renan Dal-Fabbro, Melyna Marques de Almeida, Leopoldo Cosme-Silva, Antonio H. C. Neto, Leda M. P. Salzedas, Luciano T. A. Cintra, João E. G. Filho","doi":"10.1111/jicd.12418","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The aim of the present study was to evaluate apical periodontitis (AP) development in rats under a chronic alcohol diet by calcium, phosphorus, and alkaline phosphatase blood levels in addition to histological and radiographic analyses.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Thirty-two rats were arranged into four groups: (a) group 1: without apical periodontitis and on a regular diet; (b) group 2: AP and on a regular diet; (c) group 3: alcoholic diet without apical periodontitis; and (d) group 4: alcoholic diet and apical periodontitis. Alcoholic solution at 20% was given throughout the 8-week experiment. AP was induced in the first molars at the end of the 7th week. At the end, the animals were anesthetized for blood collection, followed by euthanasia, and jaws were removed for digital radiography and histological processing. The level of significance was 5%.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Calcium levels remained constant in all groups (<i>P </i>><i> </i>0.05). Group 4 showed a higher phosphorous level than group 2 (<i>P </i><<i> </i>0.05). The alkaline phosphatase activity was higher in group 3 compared with group 1 (<i>P </i><<i> </i>0.05). Three animals in group 4 exhibited a severe inflammatory reaction, whereas the animals in group 2 did not demonstrate any reaction (<i>P </i><<i> </i>0.05). The lowest value of radiographic density was given by group 4 (<i>P </i><<i> </i>0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Chronic alcohol consumption increased serum phosphorus and decreased bone density in the periapical region, favoring AP development.</p>\n </section>\n </div>","PeriodicalId":16204,"journal":{"name":"Journal of Investigative and Clinical Dentistry","volume":"10 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jicd.12418","citationCount":"7","resultStr":"{\"title\":\"Chronic alcohol consumption changes blood marker profile and bone density in rats with apical periodontitis\",\"authors\":\"Renan Dal-Fabbro, Melyna Marques de Almeida, Leopoldo Cosme-Silva, Antonio H. C. Neto, Leda M. P. Salzedas, Luciano T. A. Cintra, João E. G. Filho\",\"doi\":\"10.1111/jicd.12418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The aim of the present study was to evaluate apical periodontitis (AP) development in rats under a chronic alcohol diet by calcium, phosphorus, and alkaline phosphatase blood levels in addition to histological and radiographic analyses.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Thirty-two rats were arranged into four groups: (a) group 1: without apical periodontitis and on a regular diet; (b) group 2: AP and on a regular diet; (c) group 3: alcoholic diet without apical periodontitis; and (d) group 4: alcoholic diet and apical periodontitis. Alcoholic solution at 20% was given throughout the 8-week experiment. AP was induced in the first molars at the end of the 7th week. At the end, the animals were anesthetized for blood collection, followed by euthanasia, and jaws were removed for digital radiography and histological processing. The level of significance was 5%.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Calcium levels remained constant in all groups (<i>P </i>><i> </i>0.05). Group 4 showed a higher phosphorous level than group 2 (<i>P </i><<i> </i>0.05). The alkaline phosphatase activity was higher in group 3 compared with group 1 (<i>P </i><<i> </i>0.05). Three animals in group 4 exhibited a severe inflammatory reaction, whereas the animals in group 2 did not demonstrate any reaction (<i>P </i><<i> </i>0.05). The lowest value of radiographic density was given by group 4 (<i>P </i><<i> </i>0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Chronic alcohol consumption increased serum phosphorus and decreased bone density in the periapical region, favoring AP development.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16204,\"journal\":{\"name\":\"Journal of Investigative and Clinical Dentistry\",\"volume\":\"10 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/jicd.12418\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Investigative and Clinical Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jicd.12418\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative and Clinical Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jicd.12418","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Chronic alcohol consumption changes blood marker profile and bone density in rats with apical periodontitis
Aim
The aim of the present study was to evaluate apical periodontitis (AP) development in rats under a chronic alcohol diet by calcium, phosphorus, and alkaline phosphatase blood levels in addition to histological and radiographic analyses.
Methods
Thirty-two rats were arranged into four groups: (a) group 1: without apical periodontitis and on a regular diet; (b) group 2: AP and on a regular diet; (c) group 3: alcoholic diet without apical periodontitis; and (d) group 4: alcoholic diet and apical periodontitis. Alcoholic solution at 20% was given throughout the 8-week experiment. AP was induced in the first molars at the end of the 7th week. At the end, the animals were anesthetized for blood collection, followed by euthanasia, and jaws were removed for digital radiography and histological processing. The level of significance was 5%.
Results
Calcium levels remained constant in all groups (P >0.05). Group 4 showed a higher phosphorous level than group 2 (P <0.05). The alkaline phosphatase activity was higher in group 3 compared with group 1 (P <0.05). Three animals in group 4 exhibited a severe inflammatory reaction, whereas the animals in group 2 did not demonstrate any reaction (P <0.05). The lowest value of radiographic density was given by group 4 (P <0.05).
Conclusions
Chronic alcohol consumption increased serum phosphorus and decreased bone density in the periapical region, favoring AP development.
期刊介绍：
Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.
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