{"title":"HLA-B27与白塞病的关联:一项系统综述和荟萃分析。","authors":"Alireza Khabbazi, Leila Vahedi, Morteza Ghojazadeh, Fariba Pashazadeh, Amin Khameneh","doi":"10.1186/s13317-019-0112-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>To calculate the genetic impact of the \"HLA-B27\" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.</p><p><strong>Methods: </strong>A systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Pooled odds ratios with 95% confidence intervals were calculated for each study. The heterogeneity of the articles was measured using the I<sup>2</sup> index.</p><p><strong>Results: </strong>Twenty two articles met the inclusion criteria for 3939 cases and 6077 controls. The pooled OR of \"HLA-B27\" in BD patients compared with controls was [1.55 (CI 95% 1.01-2.38), P = 0.04]. The OR differ among different countries or geographical areas, focus on domination the European countries. Quality of studies was moderate and heterogeneity was relatively high (I<sup>2</sup> = 66.9%).</p><p><strong>Conclusions: </strong>There is a significant correlation between HLA-B27 and Behcet's Disease, but it was weak. Environmental and genetic factors might determine which the \"HLA-B27\" alleles manifest Behcet's disease progression. Future researches is required to perform about what factors can do to positively and separately influence Behcet's disease.</p>","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"10 1","pages":"2"},"PeriodicalIF":0.0000,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s13317-019-0112-x","citationCount":"10","resultStr":"{\"title\":\"Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis.\",\"authors\":\"Alireza Khabbazi, Leila Vahedi, Morteza Ghojazadeh, Fariba Pashazadeh, Amin Khameneh\",\"doi\":\"10.1186/s13317-019-0112-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>To calculate the genetic impact of the \\\"HLA-B27\\\" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.</p><p><strong>Methods: </strong>A systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Pooled odds ratios with 95% confidence intervals were calculated for each study. The heterogeneity of the articles was measured using the I<sup>2</sup> index.</p><p><strong>Results: </strong>Twenty two articles met the inclusion criteria for 3939 cases and 6077 controls. The pooled OR of \\\"HLA-B27\\\" in BD patients compared with controls was [1.55 (CI 95% 1.01-2.38), P = 0.04]. The OR differ among different countries or geographical areas, focus on domination the European countries. Quality of studies was moderate and heterogeneity was relatively high (I<sup>2</sup> = 66.9%).</p><p><strong>Conclusions: </strong>There is a significant correlation between HLA-B27 and Behcet's Disease, but it was weak. Environmental and genetic factors might determine which the \\\"HLA-B27\\\" alleles manifest Behcet's disease progression. Future researches is required to perform about what factors can do to positively and separately influence Behcet's disease.</p>\",\"PeriodicalId\":8655,\"journal\":{\"name\":\"Auto-Immunity Highlights\",\"volume\":\"10 1\",\"pages\":\"2\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s13317-019-0112-x\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Auto-Immunity Highlights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s13317-019-0112-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Auto-Immunity Highlights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13317-019-0112-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 10
摘要
背景:通过对病例对照文献的系统回顾和荟萃分析，计算“HLA-B27”等位基因对白塞病(BD)进展风险的遗传影响。方法:系统回顾检索1975年至2017年8月PubMed、Scopus、ProQuest、EMBASE、SID、Magiran、IranDoc和IranMedex数据库中关于Behcet病的MeSH关键词、HLAB27和B27。数据在CMA2软件中进行meta分析(随机效应模型)。为每项研究计算95%置信区间的合并优势比。用I2指数衡量文章的异质性。结果:22篇文章符合纳入标准，3939例，对照6077例。与对照组相比，“HLA-B27”在BD患者中的合并OR为[1.55 (CI 95% 1.01-2.38)， P = 0.04]。不同国家或地理区域的OR不同，重点是支配欧洲国家。研究质量中等，异质性较高(I2 = 66.9%)。结论:HLA-B27与白塞病有显著相关性，但相关性较弱。环境和遗传因素可能决定哪些“HLA-B27”等位基因表现出白塞氏病的进展。未来的研究需要执行哪些因素可以做积极的和单独的影响白塞病。
Association of HLA-B27 and Behcet's disease: a systematic review and meta-analysis.
Background: To calculate the genetic impact of the "HLA-B27" allele on the risk of Behcet's disease (BD) progression using a systematic review and meta-analysis on case control papers.
Methods: A systematic review search was conducted on the MeSH keywords of Behcet's disease, HLAB27 and B27 in PubMed, Scopus, ProQuest, EMBASE, SID, Magiran, IranDoc and IranMedex databases from 1975 to Aug 2017. Data underwent meta-analysis (random effect model) in CMA2 software. Pooled odds ratios with 95% confidence intervals were calculated for each study. The heterogeneity of the articles was measured using the I2 index.
Results: Twenty two articles met the inclusion criteria for 3939 cases and 6077 controls. The pooled OR of "HLA-B27" in BD patients compared with controls was [1.55 (CI 95% 1.01-2.38), P = 0.04]. The OR differ among different countries or geographical areas, focus on domination the European countries. Quality of studies was moderate and heterogeneity was relatively high (I2 = 66.9%).
Conclusions: There is a significant correlation between HLA-B27 and Behcet's Disease, but it was weak. Environmental and genetic factors might determine which the "HLA-B27" alleles manifest Behcet's disease progression. Future researches is required to perform about what factors can do to positively and separately influence Behcet's disease.
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