天然产物给药:一个特殊的挑战?

Q1 Pharmacology, Toxicology and Pharmaceutics

Progress in medicinal chemistry Pub Date : 2019-01-01 Epub Date: 2019-03-01 DOI:10.1016/bs.pmch.2019.01.001

Neil J Press, Emilie Joly, Peter Ertl

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引用次数: 9

摘要

天然产物在药物开发和医疗用途方面具有长期和关键的作用。天然产物的结构和物理化学性质，虽然进化衍生为在生命系统中有效，但在转化为药物产品时可能会产生挑战。分子复杂性、低溶解度、官能团反应性和一般不稳定性是通常需要克服的挑战。本综述着眼于天然产品的配方和交付的一些方式，以使这些至关重要的药物成功地应用于患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural product drug delivery: A special challenge?

Natural products have a long-standing and critical role in drug development and medical use. The structural and physicochemical properties of natural products, while derived evolutionarily to be effective in living systems, may create challenges in translation to a pharmaceutical product. Molecular complexity, low solubility, functional group reactivity and general instability are among the challenges that typically need to be overcome. This review looks at some of the ways that natural products have been formulated and delivered to enable the successful application of these vitally important medicines to patients.

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来源期刊

Progress in medicinal chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

15.60

自引率

0.00%

发文量

期刊介绍： This series has a long established reputation for excellent coverage of almost every facet of Medicinal Chemistry and is one of the most respected and instructive sources of information on the subject. The latest volume certifies to the continuing success of a unique series reflecting current progress in a broadly developing field of science.