抗溃疡药物药理评价筛选模型综述

IF 3.2 Q2 Pharmacology, Toxicology and Pharmaceutics
Abhinav P Mishra, Ankit Bajpai, Suresh Chandra
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引用次数: 13

摘要

背景:由于不适当的饮食、吸烟、饮酒、经常使用非甾体抗炎药等药物以及久坐不动的生活方式,一个人可能会感到上腹部疼痛,这可能是消化道疾病消化性溃疡的预测因子。当胃的防御因子和侵袭因子之间发生不平衡时,就会在食管内膜、胃或十二指肠形成溃疡。这导致形成小疮,引起疼痛。伴随腹痛的另一种情况是呕吐类似咖啡渣的物质,大便带血,黑色或焦油样大便。这种疼痛可能在午餐或晚餐后加重。这个问题持续存在,通常会导致胃肠病学家的咨询。目的:目前已有多种抗溃疡筛选模型,可用于测定药物分子的抗溃疡活性。本研究的主要目的是找出哪种模型最适合测定抗溃疡活性。方法:在Science direct和PubMed数据库中以“Anti-ulcer”、“In-vitro models”、“In-vivo models”等不同关键词进行文献检索。搜索是通过应用适当的过滤器定制的,以便获得最相关的文章,以满足这篇综述文章的目标。结果:基于抗溃疡筛选模型测定新药分子抗溃疡活性的研究和综述文献不同。结论:在我们研究的基础上,我们发现了一些有用的药物抗溃疡活性模型,并建议如果我们将体外和体内方法结合起来,那么我们可能会得到我们研究领域最相关的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comprehensive Review on the Screening Models for the Pharmacological Assessment of Antiulcer Drugs.

Background: Due to inappropriate diet, smoking, alcohol consumption, regular use of drugs like NSAIDs and sedentary lifestyle, one may feel upper abdominal pain which may be the predictor of the gastrointestinal disorder called Peptic Ulcer. When an imbalance occurs between the defensive factor and aggressive factor of the stomach, ulcer formation in the esophageal lining, stomach, or duodenum takes place. This leads to the formation of small sores that cause pain. Another condition that synergizes the abdominal pain is vomiting materials which look like coffee grounds, blood in the stool, black or tarry stools. This pain may increase after lunch or dinner. This problem persists, that often leads to the gastroenterologist's consultation.

Objective: There are many antiulcer screening models present for the determination of antiulcer activity of the drug molecule. The main objective of this study is to find which model is best for the determination of antiulcer activity.

Methods: A literature search was conducted on the databases namely Science direct and PubMed with the help of different keywords such as "Anti-ulcer", "In-vitro models" and "In-vivo models". The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article.

Result: There are different research and review papers based on the antiulcer screening models for the determination of antiulcer activity of new drug molecules.

Conclusion: On the basis of our study, we found some useful models for the antiulcer activity of drugs and suggested that, if we use in-vitro and in-vivo methods together, then we may obtain the most relevant result in our research area.

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来源期刊
Current clinical pharmacology
Current clinical pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
3.60
自引率
0.00%
发文量
0
期刊介绍: Current Clinical Pharmacology publishes frontier reviews on all the latest advances in clinical pharmacology. The journal"s aim is to publish the highest quality review articles in the field. Topics covered include: pharmacokinetics; therapeutic trials; adverse drug reactions; drug interactions; drug metabolism; pharmacoepidemiology; and drug development. The journal is essential reading for all researchers in clinical pharmacology.
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