通过在元认知训练的标准治疗中加入认知补救疗法来改善精神分裂症的神经认知功能。

IF 9 Q1 PSYCHIATRY
Mental Illness Pub Date : 2018-12-20 eCollection Date: 2018-11-06 DOI:10.4081/mi.2018.7812
Pasquale Caponnetto, Marilena Maglia, Roberta Auditore, Marta Bocchieri, Antonio Caruso, Jennifer DiPiazza, Riccardo Polosa
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引用次数: 4

摘要

认知功能障碍是精神分裂症的常见临床特征,是影响患者预后的重要指标。因此,我们进行了一项随机、对照、单中心、单盲试验,比较两种不同的康复策略对精神分裂症住院患者认知功能的恢复和恢复。选择110名住院患者作为样本,在实验期间,55名患者接受一系列领域特异性练习(SRT+CRT)治疗,而同等数量的对照组接受属于Cogpack®软件的非领域特异性练习(SRT+PBO)治疗。分析变量治疗与时间、交互时间X对得分(T0与T1之间)的影响:对于总BACS,因子间变量治疗的主作用有统计学意义(F=201.562 P=0.000),因子内变量“时间”的主作用有统计学意义(F=496.68 P=0.000)。两因素的交互作用也具有统计学意义(F=299.594 P=0.000)。认知修复疗法(CRT)在元认知训练(MCT)标准治疗的基础上增加,导致整体神经认知功能的显著改善,并在T1时加强言语和工作记忆,选择性和持续注意力方面有积极作用。一个相关的结果是“时间X治疗”对所有进行的测试具有统计学意义:我们可以假设特定领域的认知训练放大了SRT的效果,因为本研究的主要和次要目标都实现了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.

Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.

Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.

Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of domain-specific exercises (SRT+CRT), whereas an equal control group was treated with sets of nondomain- specific exercises (SRT+PBO) belonging to the Cogpack® software. The effects on the scores (between T0 and T1) of the variables treatment and time and of the interaction time X treatment were analyzed: for the total BACS, the main effect of the between-factors variable treatment is statistically significant (F=201.562 P=0.000), as well as the effect of the within-factors variable "time" (F=496.68 P=0.000).The interaction of these two factors is also statistically significant (F=299.594 P=0.000). The addition of cognitive remediation therapy (CRT) to a standard treatment of metacognitive training (MCT) resulted in a significant improvement in global neurocognitive functioning and has reported positive effects with regard to the strengthening of verbal and working memory, selective and sustained attention at T1. A relevant result is the statistically significance of "time X treatment" for all the tests administered: we can assume that the domain-specific cognitive training amplifies the effects of SRT, as the primary and secondary goals of the present study were achieved.

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来源期刊
Mental Illness
Mental Illness PSYCHIATRY-
CiteScore
1.10
自引率
0.00%
发文量
3
审稿时长
10 weeks
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