Pasquale Caponnetto, Marilena Maglia, Roberta Auditore, Marta Bocchieri, Antonio Caruso, Jennifer DiPiazza, Riccardo Polosa
{"title":"通过在元认知训练的标准治疗中加入认知补救疗法来改善精神分裂症的神经认知功能。","authors":"Pasquale Caponnetto, Marilena Maglia, Roberta Auditore, Marta Bocchieri, Antonio Caruso, Jennifer DiPiazza, Riccardo Polosa","doi":"10.4081/mi.2018.7812","DOIUrl":null,"url":null,"abstract":"<p><p>Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of <i>domain-specific</i> exercises (SRT+CRT), whereas an equal control group was treated with sets of <i>nondomain- specific</i> exercises (SRT+PBO) belonging to the Cogpack® software. The effects on the scores (between T0 and T1) of the variables <i>treatment</i> and <i>time</i> and of the interaction <i>time X treatment</i> were analyzed: for the total BACS, the <i>main effect</i> of the <i>between-factors</i> variable <i>treatment</i> is statistically significant (F=201.562 P=0.000), as well as the effect of the <i>within-factors</i> variable \"<i>time</i>\" (F=496.68 P=0.000).The interaction of these two factors is also statistically significant (F=299.594 P=0.000). The addition of cognitive remediation therapy (CRT) to a standard treatment of metacognitive training (MCT) resulted in a significant improvement in global neurocognitive functioning and has reported positive effects with regard to the strengthening of <i>verbal</i> and <i>working memory, selective</i> and <i>sustained attention</i> at T1. A relevant result is the statistically significance of \"<i>time X treatment</i>\" for all the tests administered: we can assume that the <i>domain-specific</i> cognitive training amplifies the effects of SRT, as the primary and secondary goals of the present study were achieved.</p>","PeriodicalId":44029,"journal":{"name":"Mental Illness","volume":null,"pages":null},"PeriodicalIF":9.0000,"publicationDate":"2018-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4081/mi.2018.7812","citationCount":"4","resultStr":"{\"title\":\"Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.\",\"authors\":\"Pasquale Caponnetto, Marilena Maglia, Roberta Auditore, Marta Bocchieri, Antonio Caruso, Jennifer DiPiazza, Riccardo Polosa\",\"doi\":\"10.4081/mi.2018.7812\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of <i>domain-specific</i> exercises (SRT+CRT), whereas an equal control group was treated with sets of <i>nondomain- specific</i> exercises (SRT+PBO) belonging to the Cogpack® software. The effects on the scores (between T0 and T1) of the variables <i>treatment</i> and <i>time</i> and of the interaction <i>time X treatment</i> were analyzed: for the total BACS, the <i>main effect</i> of the <i>between-factors</i> variable <i>treatment</i> is statistically significant (F=201.562 P=0.000), as well as the effect of the <i>within-factors</i> variable \\\"<i>time</i>\\\" (F=496.68 P=0.000).The interaction of these two factors is also statistically significant (F=299.594 P=0.000). The addition of cognitive remediation therapy (CRT) to a standard treatment of metacognitive training (MCT) resulted in a significant improvement in global neurocognitive functioning and has reported positive effects with regard to the strengthening of <i>verbal</i> and <i>working memory, selective</i> and <i>sustained attention</i> at T1. A relevant result is the statistically significance of \\\"<i>time X treatment</i>\\\" for all the tests administered: we can assume that the <i>domain-specific</i> cognitive training amplifies the effects of SRT, as the primary and secondary goals of the present study were achieved.</p>\",\"PeriodicalId\":44029,\"journal\":{\"name\":\"Mental Illness\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":9.0000,\"publicationDate\":\"2018-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4081/mi.2018.7812\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mental Illness\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4081/mi.2018.7812\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/11/6 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mental Illness","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/mi.2018.7812","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/11/6 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Improving neurocognitive functioning in schizophrenia by addition of cognitive remediation therapy to a standard treatment of metacognitive training.
Cognitive dysfunctions are a common clinical feature of schizophrenia and represent important indicators of outcome among patients who are affected. Therefore, a randomized, controlled, monocentric, singleblind trial was carried out to compare two different rehabilitation strategies adopted for the restoration and recovery of cognitive functioning of residential patients with schizophrenia. A sample of 110 residential patients were selected and, during the experimental period, a group of 55 patients was treated with sets of domain-specific exercises (SRT+CRT), whereas an equal control group was treated with sets of nondomain- specific exercises (SRT+PBO) belonging to the Cogpack® software. The effects on the scores (between T0 and T1) of the variables treatment and time and of the interaction time X treatment were analyzed: for the total BACS, the main effect of the between-factors variable treatment is statistically significant (F=201.562 P=0.000), as well as the effect of the within-factors variable "time" (F=496.68 P=0.000).The interaction of these two factors is also statistically significant (F=299.594 P=0.000). The addition of cognitive remediation therapy (CRT) to a standard treatment of metacognitive training (MCT) resulted in a significant improvement in global neurocognitive functioning and has reported positive effects with regard to the strengthening of verbal and working memory, selective and sustained attention at T1. A relevant result is the statistically significance of "time X treatment" for all the tests administered: we can assume that the domain-specific cognitive training amplifies the effects of SRT, as the primary and secondary goals of the present study were achieved.