中枢致敏的表型特征

Q1 Social Sciences

JOURNAL OF APPLIED BIOBEHAVIORAL RESEARCH Pub Date : 2018-06-27 DOI:10.1111/jabr.12135

David A. Williams

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引用次数: 43

摘要

目前的手稿回顾了表型中心致敏(CS)的方法。手稿涵盖了诊断表型的概念，使用内表型，生物标志物和症状集群。具体来说，CS的组成部分包括一般感觉敏感性(通过定量感觉测试评估)和表征睡眠困难、疼痛、情绪、认知困难和低能量的症状群(S.P.A.C.E.)。每个评估领域都是根据CS及其在慢性重叠疼痛条件(COPCs)中的存在进行描述的-这些条件可能受到CS的影响。慢性重叠疼痛状况可能代表CS的临床诊断表型。还可以使用QST或自我报告工具来评估CS的组成部分，这些工具旨在评估CS的单个元素或更一般的复合指数。

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Phenotypic features of central sensitization

The current manuscript reviews approaches for phenotyping central sensitization (CS).

The manuscript covers the concept of diagnostic phenotyping, use of endophenotypes, biomarkers, and symptom clusters. Specifically, the components of CS that include general sensory sensitivity (assessed by quantitative sensory testing) and a symptom cluster denoting sleep difficulties, pain, affect, cognitive difficulties, and low energy (S.P.A.C.E.).

Each of the assessment domains are described with reference to CS and their presence in chronic overlapping pain conditions (COPCs)—conditions likely influenced by CS.

Chronic overlapping pain conditions likely represent clinical diagnostic phenotypes of CS. Components of CS can also be assessed using QST or self-report instruments designed to assess single elements of CS or more general composite indices.

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来源期刊

JOURNAL OF APPLIED BIOBEHAVIORAL RESEARCH PSYCHOLOGY, CLINICAL-

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： The Journal of Applied Biobehavioral Research, launched in 1993, aims to disseminate findings of behavioral science research which have applications to current problems of society. By publishing relevant research and emphasizing the excellence of experimental design, as well as potential applicability of experimental results, the journal bridges the theoretical and applied areas of biobehavioral research. The Journal of Applied Biobehavioral Research serves as a means of communication among scientists, as well as between researchers and those engaged in the task of solving social and biomedical problems.