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引用次数: 12
摘要
银屑病是一种慢性、复发性炎症性皮肤病,其特征是角化细胞异常增殖、血管增生、炎症细胞浸润到真皮和表皮。人们普遍认为银屑病的核心发病机制是T淋巴细胞功能障碍,而T淋巴细胞功能障碍受遗传和环境因素的复杂相互作用影响,包括创伤、感染、压力、药物、吸烟和饮酒(Nestle et al., 2009)。环境诱导的表观遗传变化,包括DNA甲基化、组蛋白修饰和microrna,已被证明参与了该疾病的发病机制(Zhang et al., 2012)。
期刊介绍:
Journal of Investigative Dermatology Symposium Proceedings (JIDSP) publishes peer-reviewed, invited papers relevant to all aspects of cutaneous biology and skin disease. Papers in the JIDSP are often initially presented at a scientific meeting. Potential topics include biochemistry, biophysics, carcinogenesis, cellular growth and regulation, clinical research, development, epidemiology and other population-based research, extracellular matrix, genetics, immunology, melanocyte biology, microbiology, molecular and cell biology, pathology, pharmacology and percutaneous absorption, photobiology, physiology, and skin structure.